Fluorescence enhancement of coumarin-6-sulfonyl chloride amino acid derivatives in cyclodextrin media

S. M Z Al-Kindy; F. E O Suliman; A. A. Al-Hamadi

doi:10.2116/analsci.17.539

Fluorescence enhancement of coumarin-6-sulfonyl chloride amino acid derivatives in cyclodextrin media

S. M Z Al-Kindy^*, F. E O Suliman, A. A. Al-Hamadi

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Coumarin-6-sulfonyl (6-CS) amino acid derivatives form inclusion complexes with α- and β-cyclodextrins (CD) in aqueous solution. The stoichiometry of the inclusion complex and the equilibrium constant were investigated. Using a fluorescence technique and alanine-β-CD as a model, a 1:2 guest-host complex was established, and K = 4.7 × 10⁵ mol^-2 l² was obtained. Fluorescence enhancement was observed for all derivatives studied, with glycine exhibiting a greater enhancement, and tyrosine showing the least. The stability of the inclusion complex was found to depend on the respective sizes of the guest-host complex and their interaction.

Original language	English
Pages (from-to)	539-543
Number of pages	5
Journal	Analytical Sciences
Volume	17
Issue number	4
DOIs	https://doi.org/10.2116/analsci.17.539
Publication status	Published - 2001

ASJC Scopus subject areas

Analytical Chemistry

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abstract = "Coumarin-6-sulfonyl (6-CS) amino acid derivatives form inclusion complexes with α- and β-cyclodextrins (CD) in aqueous solution. The stoichiometry of the inclusion complex and the equilibrium constant were investigated. Using a fluorescence technique and alanine-β-CD as a model, a 1:2 guest-host complex was established, and K = 4.7 × 105 mol-2 l2 was obtained. Fluorescence enhancement was observed for all derivatives studied, with glycine exhibiting a greater enhancement, and tyrosine showing the least. The stability of the inclusion complex was found to depend on the respective sizes of the guest-host complex and their interaction.",

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AB - Coumarin-6-sulfonyl (6-CS) amino acid derivatives form inclusion complexes with α- and β-cyclodextrins (CD) in aqueous solution. The stoichiometry of the inclusion complex and the equilibrium constant were investigated. Using a fluorescence technique and alanine-β-CD as a model, a 1:2 guest-host complex was established, and K = 4.7 × 105 mol-2 l2 was obtained. Fluorescence enhancement was observed for all derivatives studied, with glycine exhibiting a greater enhancement, and tyrosine showing the least. The stability of the inclusion complex was found to depend on the respective sizes of the guest-host complex and their interaction.

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