Flow injection spectrophotometric determination of the antibiotic ciprofloxacin in drug formulations

Salah M. Sultan, Fakhr Eldin O Suliman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

A flow injection spectrophotometric method for the assay of ciprofloxacin was developed. The method was based on the chelation of iron(III) with the drug in 0.023 mol dm-3 sulfuric acid solution in a 72 cm long coil and the brown-red complex produced was monitored at 447 nm. The super modified simplex computer program was employed for the optimization of the system and chemical parameters with respect to throughput and sensitivity as a measure of system performance. A working range for ciprofloxacin determination of 50-500 ppm for a 110 mm3 sample size with an optimum of 250 samples per hour was achieved with a relative standard deviation of less than 0.92%. The method was successfully applied to the determination of ciprofloxacin in drug formulations.

Original languageEnglish
Pages (from-to)1523-1526
Number of pages4
JournalAnalyst
Volume117
Issue number9
Publication statusPublished - 1992

Fingerprint

Drug Compounding
Antibiotics
Ciprofloxacin
Chelation
Sulfuric acid
antibiotics
Computer program listings
Assays
drug
Throughput
Iron
Anti-Bacterial Agents
Injections
chelation
Sample Size
sulfuric acid
Software
assay
software
iron

Keywords

  • Ciprofloxacin
  • Drug formulation
  • Flow injection
  • Iron(III)
  • Super modified simplex optimization

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Flow injection spectrophotometric determination of the antibiotic ciprofloxacin in drug formulations. / Sultan, Salah M.; Suliman, Fakhr Eldin O.

In: Analyst, Vol. 117, No. 9, 1992, p. 1523-1526.

Research output: Contribution to journalArticle

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