Flow-based analysis using microfluidics-chemiluminescence systems

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This review will discuss various approaches and techniques in which analysis using microfluidics-chemiluminescence systems (MF-CL) has been reported. A variety of applications is examined, including environmental, pharmaceutical, biological, food and herbal analysis. Reported uses of CL reagents, sample introduction techniques, sample pretreatment methods, CL signal enhancement and detection systems are discussed. A hydrodynamic pumping system is predominately used for these applications. However, several reports are available in which electro-osmotic (EO) pumping has been implemented. Various sample pretreatment methods have been used, including liquid-liquid extraction, solid-phase extraction and molecularly imprinted polymers. A wide range of innovative techniques has been reported for CL signal enhancement. Most of these techniques are based on enhancement of the mixing process in the microfluidics channels, which leads to enhancement of the CL signal. However, other techniques are also reported, such as mirror reaction, liquid core waveguide, on-line pre-derivatization and the use of an opaque white chip with a thin transparent seal. Photodetectors are the most commonly used detectors; however, other detection systems have also been used, including integrated electrochemiluminescence (ECL) and organic photodiodes (OPDs).

Original languageEnglish
Pages (from-to)618-627
Number of pages10
JournalLuminescence
Volume28
Issue number5
DOIs
Publication statusPublished - Sep 2013

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Microfluidic Analytical Techniques
Chemiluminescence
Luminescence
Microfluidics
Food Analysis
Liquid-Liquid Extraction
Solid Phase Extraction
Liquids
Hydrodynamics
Polymers
Telephone lines
Photodetectors
Photodiodes
Seals
Mirrors
Waveguides
Pharmaceutical Preparations
Detectors

Keywords

  • chemiluminescence
  • electrochemiluminescence
  • microfluidics

ASJC Scopus subject areas

  • Biophysics
  • Chemistry (miscellaneous)
  • Medicine(all)

Cite this

Flow-based analysis using microfluidics-chemiluminescence systems. / Al Lawati, Haider A J.

In: Luminescence, Vol. 28, No. 5, 09.2013, p. 618-627.

Research output: Contribution to journalArticle

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