Abstract
We report the presence of two different δ-globin gene mutations causing δ+-thalassemia in association with homozygous (-α3.7/-α3.7) genotype for the first time in an Omani child with a low hemoglobin A2 (HbA2) of 0.8 %. Direct nucleotide sequencing revealed compound heterozygote mutations in the patient's δ-globin genes: HbA2-Yialousa (HBD: c.82G>C) and HbA2-Wrens (HBD: c.295G>A). In Oman, where α and β-thalassemia and HbS are prevalent, an awareness of the presence of different δ-globin gene mutations is important as complex interactions between these hemoglobinopathies can lead to the misdiagnosis of β-thalassemia carriers.
Original language | English |
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Pages (from-to) | 240-242 |
Number of pages | 3 |
Journal | International Journal of Hematology |
Volume | 98 |
Issue number | 2 |
DOIs | |
Publication status | Published - Aug 2013 |
Keywords
- HbA-Wrens
- HbA-Yialousa
- Oman
- δ-Thalassemia
ASJC Scopus subject areas
- Hematology