First pass FDG measured blood flow in tumors

A comparison with O-15 labeled water measured blood flow

N. A. Mullani, R. S. Herbst, J. L. Abbruzzese, B. Barron, L. Lamki, C. Charnsangavej, E. Kim, H. T. Tran, A. Jiwani, K. L. Gould

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The purpose of this study was to determine if the first-pass of FDG can be used to measure regional blood flow in tumors in the absence of perfusion imaging with a known blood flow tracer. PET scans were obtained in patients being evaluated for tumor perfusion and metabolism in a Phase I dose escalating protocol for Endostatin, a novel antiangiogenic agent. A two minutes perfusion scan was done with a bolus injection of 60 mCi of O-15 labeled water followed by a 10 mCi dose of FDG and four sequential scans consisting of a first pass two minutes scan and three 15 minutes scans. Regions of interest were drawn on two tumor sites for each scan. Blood flow was computed using a one-compartment model previously published by the authors. Linear regression analysis was carried out between the first pass FDG measured blood flow and O-15 measured blood flow (Figure 1). (Figure Presented) (5K) Figure 1. Blood flow estimated from the first pass of FDG was linearly correlated with 0-15 measured blood flow with an intercept of 0.01, slope of 0.86, and r squared regression coefficient of 0.74 (R = 0.86) for blood flow values of up to 0.6 ml/min/gm of tissue. These results suggests that in the absence of a perfusion tracer, the first pass of FDG provides an estimate of perfusion in a tumor within the limitations of incomplete extraction of FDG compared to O-15 water.

Original languageEnglish
Pages (from-to)153
Number of pages1
JournalClinical Positron Imaging (Netherlands)
Volume3
Issue number4
DOIs
Publication statusPublished - 2000

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Water
Perfusion
Neoplasms
Endostatins
Angiogenesis Inhibitors
Perfusion Imaging
Regional Blood Flow
Positron-Emission Tomography
Linear Models
Regression Analysis
Injections

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

First pass FDG measured blood flow in tumors : A comparison with O-15 labeled water measured blood flow. / Mullani, N. A.; Herbst, R. S.; Abbruzzese, J. L.; Barron, B.; Lamki, L.; Charnsangavej, C.; Kim, E.; Tran, H. T.; Jiwani, A.; Gould, K. L.

In: Clinical Positron Imaging (Netherlands), Vol. 3, No. 4, 2000, p. 153.

Research output: Contribution to journalReview article

Mullani, NA, Herbst, RS, Abbruzzese, JL, Barron, B, Lamki, L, Charnsangavej, C, Kim, E, Tran, HT, Jiwani, A & Gould, KL 2000, 'First pass FDG measured blood flow in tumors: A comparison with O-15 labeled water measured blood flow', Clinical Positron Imaging (Netherlands), vol. 3, no. 4, pp. 153. https://doi.org/10.1016/S1095-0397(00)00065-0
Mullani, N. A. ; Herbst, R. S. ; Abbruzzese, J. L. ; Barron, B. ; Lamki, L. ; Charnsangavej, C. ; Kim, E. ; Tran, H. T. ; Jiwani, A. ; Gould, K. L. / First pass FDG measured blood flow in tumors : A comparison with O-15 labeled water measured blood flow. In: Clinical Positron Imaging (Netherlands). 2000 ; Vol. 3, No. 4. pp. 153.
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