Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease

Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Gilles J. Guillemin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and is characterized by the progressive loss of the hippocampal and cortical neurons, which results in memory and cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic and anti-diabetic properties. Traditionally, it was used as a galactagogue and to treat anorexia, fever gastritis, gastric ulcers, and various nervous disorders. However, the neuroprotective effect of fenugreek seed powder against aluminum chloride (AlCl3) induced AD rats has not been analyzed. The result of the present study indicated that the chronic administration of AlCl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of IDE and CDK5 (enzymes involved in the metabolism of tau and amyloid proteins), pTau, GFAP and Iba-1, IL-1β, IL-6, TNF-α, iNOS, NF-κB, COX-2, CDK5, BDNF, and STAT3. Our behavioral, biochemical, and molecular studies revealed that the co-Administration of fenugreek seed powder significantly attenuated the AlCl3 induced memory deficits, amyloid and tau pathology, oxidative stress, and inflammation in AD rats could be due to the synergistic action of its active components.

Original languageEnglish
Pages (from-to)S209-S220
JournalJournal of Alzheimer's Disease
Volume60
Issue numbers1
DOIs
Publication statusPublished - 2017

Fingerprint

Trigonella
Powders
Seeds
Alzheimer Disease
Oxidative Stress
Pathology
Inflammation
Amyloidogenic Proteins
tau Proteins
Brain-Derived Neurotrophic Factor
Memory Disorders
Anorexia
Neuroprotective Agents
Gastritis
Stomach Ulcer
Interleukin-1
Hypoglycemic Agents
Amyloid
Neurodegenerative Diseases
Interleukin-6

Keywords

  • Alzheimer's disease
  • fenugreek seeds
  • inflammation
  • neuroprotection
  • oxidative stress tau pathology

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. / Prema, Asokan; Justin Thenmozhi, Arokiasamy; Manivasagam, Thamilarasan; Mohamed Essa, Musthafa; Guillemin, Gilles J.

In: Journal of Alzheimer's Disease, Vol. 60, No. s1, 2017, p. S209-S220.

Research output: Contribution to journalArticle

Prema, Asokan ; Justin Thenmozhi, Arokiasamy ; Manivasagam, Thamilarasan ; Mohamed Essa, Musthafa ; Guillemin, Gilles J. / Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. In: Journal of Alzheimer's Disease. 2017 ; Vol. 60, No. s1. pp. S209-S220.
@article{59083ff33b7d435781f2e0e0ff64050b,
title = "Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease",
abstract = "Alzheimer's disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and is characterized by the progressive loss of the hippocampal and cortical neurons, which results in memory and cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic and anti-diabetic properties. Traditionally, it was used as a galactagogue and to treat anorexia, fever gastritis, gastric ulcers, and various nervous disorders. However, the neuroprotective effect of fenugreek seed powder against aluminum chloride (AlCl3) induced AD rats has not been analyzed. The result of the present study indicated that the chronic administration of AlCl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of IDE and CDK5 (enzymes involved in the metabolism of tau and amyloid proteins), pTau, GFAP and Iba-1, IL-1β, IL-6, TNF-α, iNOS, NF-κB, COX-2, CDK5, BDNF, and STAT3. Our behavioral, biochemical, and molecular studies revealed that the co-Administration of fenugreek seed powder significantly attenuated the AlCl3 induced memory deficits, amyloid and tau pathology, oxidative stress, and inflammation in AD rats could be due to the synergistic action of its active components.",
keywords = "Alzheimer's disease, fenugreek seeds, inflammation, neuroprotection, oxidative stress tau pathology",
author = "Asokan Prema and {Justin Thenmozhi}, Arokiasamy and Thamilarasan Manivasagam and {Mohamed Essa}, Musthafa and Guillemin, {Gilles J.}",
year = "2017",
doi = "10.3233/JAD-161103",
language = "English",
volume = "60",
pages = "S209--S220",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "s1",

}

TY - JOUR

T1 - Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease

AU - Prema, Asokan

AU - Justin Thenmozhi, Arokiasamy

AU - Manivasagam, Thamilarasan

AU - Mohamed Essa, Musthafa

AU - Guillemin, Gilles J.

PY - 2017

Y1 - 2017

N2 - Alzheimer's disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and is characterized by the progressive loss of the hippocampal and cortical neurons, which results in memory and cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic and anti-diabetic properties. Traditionally, it was used as a galactagogue and to treat anorexia, fever gastritis, gastric ulcers, and various nervous disorders. However, the neuroprotective effect of fenugreek seed powder against aluminum chloride (AlCl3) induced AD rats has not been analyzed. The result of the present study indicated that the chronic administration of AlCl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of IDE and CDK5 (enzymes involved in the metabolism of tau and amyloid proteins), pTau, GFAP and Iba-1, IL-1β, IL-6, TNF-α, iNOS, NF-κB, COX-2, CDK5, BDNF, and STAT3. Our behavioral, biochemical, and molecular studies revealed that the co-Administration of fenugreek seed powder significantly attenuated the AlCl3 induced memory deficits, amyloid and tau pathology, oxidative stress, and inflammation in AD rats could be due to the synergistic action of its active components.

AB - Alzheimer's disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and is characterized by the progressive loss of the hippocampal and cortical neurons, which results in memory and cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic and anti-diabetic properties. Traditionally, it was used as a galactagogue and to treat anorexia, fever gastritis, gastric ulcers, and various nervous disorders. However, the neuroprotective effect of fenugreek seed powder against aluminum chloride (AlCl3) induced AD rats has not been analyzed. The result of the present study indicated that the chronic administration of AlCl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of IDE and CDK5 (enzymes involved in the metabolism of tau and amyloid proteins), pTau, GFAP and Iba-1, IL-1β, IL-6, TNF-α, iNOS, NF-κB, COX-2, CDK5, BDNF, and STAT3. Our behavioral, biochemical, and molecular studies revealed that the co-Administration of fenugreek seed powder significantly attenuated the AlCl3 induced memory deficits, amyloid and tau pathology, oxidative stress, and inflammation in AD rats could be due to the synergistic action of its active components.

KW - Alzheimer's disease

KW - fenugreek seeds

KW - inflammation

KW - neuroprotection

KW - oxidative stress tau pathology

UR - http://www.scopus.com/inward/record.url?scp=85029485597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029485597&partnerID=8YFLogxK

U2 - 10.3233/JAD-161103

DO - 10.3233/JAD-161103

M3 - Article

VL - 60

SP - S209-S220

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - s1

ER -