Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus

Aliya Alansari, Ahmet Gul, Murat Inanc, Jose Ordi, Lee Suan Teh, William E. Ollier, Miguel A. Gonzalez-Gay, Ali H. Hajeer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To investigate the possible association between Fc receptor (FcR) gamma polymorphisms and systemic lupus erythematosus (SLE). Methods: We have investigated the full FcR gamma gene for polymorphisms using polymerase chain reaction (PCR)-single strand conformational polymorphism and DNA sequencing. The polymorphisms identified were genotype using PCR-restriction fragment length polymorphism. Systemic lupus erythematosus cases and controls were available from 3 ethnic groups: Turkish, Spanish and Caucasian. The study was conducted in the year 2001 at the Arthritis Research Campaign, Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom. Results: Five single nucleotide polymorphisms were identified, 2 in the promoter, one in intron 4 and, 2 in the 3'UTR. Four of the 5 single nucleotide polymorphisms (SNPs) were relatively common and investigated in the 3 populations. Allele and genotype frequencies of all 4 investigated SNPs were not statistically different between cases and controls. Conclusion: Fc receptor gamma gene does not appear to contribute to SLE susceptibility. The identified polymorphisms may be useful in investigating other diseases where receptors containing the FcR gamma subunit contribute to the pathology.

Original languageEnglish
Pages (from-to)1445-1448
Number of pages4
JournalSaudi Medical Journal
Volume25
Issue number10
Publication statusPublished - Oct 2004

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IgG Receptors
Systemic Lupus Erythematosus
Single Nucleotide Polymorphism
Genotype
Polymerase Chain Reaction
3' Untranslated Regions
Medical Schools
DNA Sequence Analysis
Ethnic Groups
Gene Frequency
Restriction Fragment Length Polymorphisms
Introns
Genes
Arthritis
Epidemiology
Pathology
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alansari, A., Gul, A., Inanc, M., Ordi, J., Teh, L. S., Ollier, W. E., ... Hajeer, A. H. (2004). Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus. Saudi Medical Journal, 25(10), 1445-1448.

Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus. / Alansari, Aliya; Gul, Ahmet; Inanc, Murat; Ordi, Jose; Teh, Lee Suan; Ollier, William E.; Gonzalez-Gay, Miguel A.; Hajeer, Ali H.

In: Saudi Medical Journal, Vol. 25, No. 10, 10.2004, p. 1445-1448.

Research output: Contribution to journalArticle

Alansari, A, Gul, A, Inanc, M, Ordi, J, Teh, LS, Ollier, WE, Gonzalez-Gay, MA & Hajeer, AH 2004, 'Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus', Saudi Medical Journal, vol. 25, no. 10, pp. 1445-1448.
Alansari A, Gul A, Inanc M, Ordi J, Teh LS, Ollier WE et al. Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus. Saudi Medical Journal. 2004 Oct;25(10):1445-1448.
Alansari, Aliya ; Gul, Ahmet ; Inanc, Murat ; Ordi, Jose ; Teh, Lee Suan ; Ollier, William E. ; Gonzalez-Gay, Miguel A. ; Hajeer, Ali H. / Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus. In: Saudi Medical Journal. 2004 ; Vol. 25, No. 10. pp. 1445-1448.
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AU - Gonzalez-Gay, Miguel A.

AU - Hajeer, Ali H.

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N2 - Objective: To investigate the possible association between Fc receptor (FcR) gamma polymorphisms and systemic lupus erythematosus (SLE). Methods: We have investigated the full FcR gamma gene for polymorphisms using polymerase chain reaction (PCR)-single strand conformational polymorphism and DNA sequencing. The polymorphisms identified were genotype using PCR-restriction fragment length polymorphism. Systemic lupus erythematosus cases and controls were available from 3 ethnic groups: Turkish, Spanish and Caucasian. The study was conducted in the year 2001 at the Arthritis Research Campaign, Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom. Results: Five single nucleotide polymorphisms were identified, 2 in the promoter, one in intron 4 and, 2 in the 3'UTR. Four of the 5 single nucleotide polymorphisms (SNPs) were relatively common and investigated in the 3 populations. Allele and genotype frequencies of all 4 investigated SNPs were not statistically different between cases and controls. Conclusion: Fc receptor gamma gene does not appear to contribute to SLE susceptibility. The identified polymorphisms may be useful in investigating other diseases where receptors containing the FcR gamma subunit contribute to the pathology.

AB - Objective: To investigate the possible association between Fc receptor (FcR) gamma polymorphisms and systemic lupus erythematosus (SLE). Methods: We have investigated the full FcR gamma gene for polymorphisms using polymerase chain reaction (PCR)-single strand conformational polymorphism and DNA sequencing. The polymorphisms identified were genotype using PCR-restriction fragment length polymorphism. Systemic lupus erythematosus cases and controls were available from 3 ethnic groups: Turkish, Spanish and Caucasian. The study was conducted in the year 2001 at the Arthritis Research Campaign, Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom. Results: Five single nucleotide polymorphisms were identified, 2 in the promoter, one in intron 4 and, 2 in the 3'UTR. Four of the 5 single nucleotide polymorphisms (SNPs) were relatively common and investigated in the 3 populations. Allele and genotype frequencies of all 4 investigated SNPs were not statistically different between cases and controls. Conclusion: Fc receptor gamma gene does not appear to contribute to SLE susceptibility. The identified polymorphisms may be useful in investigating other diseases where receptors containing the FcR gamma subunit contribute to the pathology.

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