Familial mineralocorticoid induced hypertension in the sultanate of Oman

Nicholas J.Y. Woodhouse, Omayma T. Elshafie, Fatma Ben Abid, Suhail A. Doi

Research output: Contribution to journalArticle

Abstract

Objectives: In Oman, many hypertensive patients with a family history of the disease respond to treatment with spironolactone, a mineralocorticoid receptor (MC-R) blocking agent thus suggesting a high prevalence of mineralocorticoid (MC) induced disease. The aim of this study was to document the prevalence of MC induced disease in patients with a positive family history of hypertension (HTN). Methods: Serum calcium, potassium, creatinine, aldosterone and renin levels were measured under standard conditions in all patients together with an abdominal ultrasound scan and an adrenal computed tomography (CT) scan in four patients. Results: In this small study, we show that 18 of the 27 patients (66%) had undetectable (suppressed) renin levels with usually normal aldosterone values (14 patients) and respond to treatment with spironoactone. Conclusion: We suggest that MC induced hypertension is likely to be common in the Middle East. In evolutionary terms, this makes sense as the ability to conserve salt in hot climates might be expected to confer a definite survival advantage.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume8
Issue number2
Publication statusPublished - Jul 1 2008

Fingerprint

Oman
Mineralocorticoids
Hypertension
Aldosterone
Renin
Mineralocorticoid Receptors
Spironolactone
Aptitude
Middle East
Climate
Creatinine
Potassium
Reference Values
Salts
Tomography
Calcium
Survival
Therapeutics
Serum

Keywords

  • Familial
  • High prevalence
  • Hypertension
  • Mineralocorticoids
  • Oman

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Familial mineralocorticoid induced hypertension in the sultanate of Oman. / Woodhouse, Nicholas J.Y.; Elshafie, Omayma T.; Abid, Fatma Ben; Doi, Suhail A.

In: Sultan Qaboos University Medical Journal, Vol. 8, No. 2, 01.07.2008, p. 165-169.

Research output: Contribution to journalArticle

Woodhouse, Nicholas J.Y. ; Elshafie, Omayma T. ; Abid, Fatma Ben ; Doi, Suhail A. / Familial mineralocorticoid induced hypertension in the sultanate of Oman. In: Sultan Qaboos University Medical Journal. 2008 ; Vol. 8, No. 2. pp. 165-169.
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