Abstract
The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single-point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications.
| Original language | English |
|---|---|
| Pages (from-to) | 307-309 |
| Number of pages | 3 |
| Journal | American Journal of Hematology |
| Volume | 76 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 2004 |
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Keywords
- Hypercoagulation
- Risk factors
- Saudi
- Sickle cell disease
ASJC Scopus subject areas
- Hematology
Cite this
Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia. / Fawaz, Naglaa A.; Bashawery, Layla; Al-Sheikh, Iman; Qatari, Ahlam; Al-Othman, Sara S.; Almawi, Wassim Y.
In: American Journal of Hematology, Vol. 76, No. 3, 07.2004, p. 307-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia
AU - Fawaz, Naglaa A.
AU - Bashawery, Layla
AU - Al-Sheikh, Iman
AU - Qatari, Ahlam
AU - Al-Othman, Sara S.
AU - Almawi, Wassim Y.
PY - 2004/7
Y1 - 2004/7
N2 - The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single-point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications.
AB - The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single-point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications.
KW - Hypercoagulation
KW - Risk factors
KW - Saudi
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=3042646355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042646355&partnerID=8YFLogxK
U2 - 10.1002/ajh.20087
DO - 10.1002/ajh.20087
M3 - Article
C2 - 15224376
AN - SCOPUS:3042646355
VL - 76
SP - 307
EP - 309
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -