Extent of subclinical pulmonary involvement in childhood onset Systemic Lupus Erythematosus in the Sultanate of Oman

Eiman Abdulla, Ibrahim Al-Zakwani, Sawsan Baddar, Reem Abdwani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: The aim of this study was to investigate the frequency of pulmonary function abnormalities in clinically asymptomatic children with Systemic Lupus Erythematosus and to determine the relationship of these abnormalities to clinical, laboratory, and immunological parameters as well as to disease activity. Methods: Forty-two children with childhood onset Systemic Lupus Erythematosus were included in this study. Demographic, clinical, laboratory and immunological parameters, as well as disease activity were assessed. Pulmonary function tests (PFT) were performed routinely to screen for subclinical lung disease. Results: Out of the 42 children, 19% (n=8) had clinical evidence of pulmonary involvement. The patients with no clinical evidence of pulmonary involvement (n=34) represent the study cohort. From our cohort of patients with no clinical evidence of pulmonary involvement 79% (n=27) had PFT abnormality; including 62% (n=21) had reduced FVC, 71% (n=24) had reduced FEV1, and 67% (n=12) had reduced DLCO. Similarly, 56% (n=15) had a restrictive PFT pattern, and 2.6% (n=2) had an obstructive PFT pattern, while 33% (n=7) had an isolated impairment of diffusion capacity. Due to small sample size; it was not possible to find a statistically significant difference between the cohort of asymptomatic SLE patients with abnormal PFT findings (n=27) and those with normal PFT findings (n=7) in terms of clinical, laboratory, immunological or disease activity index score. Conclusion: Subclinical lung disease, as demonstrated by abnormal PFT in patients with normal radiographs, may be common but should be interpreted with caution as an early sign of lung disease. Although PFT studies do not correlate well with pulmonary symptoms in patients with childhood onset SLE, they nevertheless provide objective quantification of the type and severity of the functional lesions.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalOman Medical Journal
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Oman
Respiratory Function Tests
Systemic Lupus Erythematosus
Lung
Lung Diseases
Immune System Diseases
Sample Size
Cohort Studies
Demography

Keywords

  • Oman
  • Prevalence
  • Pulmonary
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Extent of subclinical pulmonary involvement in childhood onset Systemic Lupus Erythematosus in the Sultanate of Oman. / Abdulla, Eiman; Al-Zakwani, Ibrahim; Baddar, Sawsan; Abdwani, Reem.

In: Oman Medical Journal, Vol. 27, No. 1, 01.2012, p. 36-39.

Research output: Contribution to journalArticle

@article{a0cd325114cb4b82a8159ca9981ef213,
title = "Extent of subclinical pulmonary involvement in childhood onset Systemic Lupus Erythematosus in the Sultanate of Oman",
abstract = "Objectives: The aim of this study was to investigate the frequency of pulmonary function abnormalities in clinically asymptomatic children with Systemic Lupus Erythematosus and to determine the relationship of these abnormalities to clinical, laboratory, and immunological parameters as well as to disease activity. Methods: Forty-two children with childhood onset Systemic Lupus Erythematosus were included in this study. Demographic, clinical, laboratory and immunological parameters, as well as disease activity were assessed. Pulmonary function tests (PFT) were performed routinely to screen for subclinical lung disease. Results: Out of the 42 children, 19{\%} (n=8) had clinical evidence of pulmonary involvement. The patients with no clinical evidence of pulmonary involvement (n=34) represent the study cohort. From our cohort of patients with no clinical evidence of pulmonary involvement 79{\%} (n=27) had PFT abnormality; including 62{\%} (n=21) had reduced FVC, 71{\%} (n=24) had reduced FEV1, and 67{\%} (n=12) had reduced DLCO. Similarly, 56{\%} (n=15) had a restrictive PFT pattern, and 2.6{\%} (n=2) had an obstructive PFT pattern, while 33{\%} (n=7) had an isolated impairment of diffusion capacity. Due to small sample size; it was not possible to find a statistically significant difference between the cohort of asymptomatic SLE patients with abnormal PFT findings (n=27) and those with normal PFT findings (n=7) in terms of clinical, laboratory, immunological or disease activity index score. Conclusion: Subclinical lung disease, as demonstrated by abnormal PFT in patients with normal radiographs, may be common but should be interpreted with caution as an early sign of lung disease. Although PFT studies do not correlate well with pulmonary symptoms in patients with childhood onset SLE, they nevertheless provide objective quantification of the type and severity of the functional lesions.",
keywords = "Oman, Prevalence, Pulmonary, Systemic lupus erythematosus",
author = "Eiman Abdulla and Ibrahim Al-Zakwani and Sawsan Baddar and Reem Abdwani",
year = "2012",
month = "1",
doi = "10.5001/omj.2012.07",
language = "English",
volume = "27",
pages = "36--39",
journal = "Oman Medical Journal",
issn = "1999-768X",
publisher = "Oman Medical Specialty Board",
number = "1",

}

TY - JOUR

T1 - Extent of subclinical pulmonary involvement in childhood onset Systemic Lupus Erythematosus in the Sultanate of Oman

AU - Abdulla, Eiman

AU - Al-Zakwani, Ibrahim

AU - Baddar, Sawsan

AU - Abdwani, Reem

PY - 2012/1

Y1 - 2012/1

N2 - Objectives: The aim of this study was to investigate the frequency of pulmonary function abnormalities in clinically asymptomatic children with Systemic Lupus Erythematosus and to determine the relationship of these abnormalities to clinical, laboratory, and immunological parameters as well as to disease activity. Methods: Forty-two children with childhood onset Systemic Lupus Erythematosus were included in this study. Demographic, clinical, laboratory and immunological parameters, as well as disease activity were assessed. Pulmonary function tests (PFT) were performed routinely to screen for subclinical lung disease. Results: Out of the 42 children, 19% (n=8) had clinical evidence of pulmonary involvement. The patients with no clinical evidence of pulmonary involvement (n=34) represent the study cohort. From our cohort of patients with no clinical evidence of pulmonary involvement 79% (n=27) had PFT abnormality; including 62% (n=21) had reduced FVC, 71% (n=24) had reduced FEV1, and 67% (n=12) had reduced DLCO. Similarly, 56% (n=15) had a restrictive PFT pattern, and 2.6% (n=2) had an obstructive PFT pattern, while 33% (n=7) had an isolated impairment of diffusion capacity. Due to small sample size; it was not possible to find a statistically significant difference between the cohort of asymptomatic SLE patients with abnormal PFT findings (n=27) and those with normal PFT findings (n=7) in terms of clinical, laboratory, immunological or disease activity index score. Conclusion: Subclinical lung disease, as demonstrated by abnormal PFT in patients with normal radiographs, may be common but should be interpreted with caution as an early sign of lung disease. Although PFT studies do not correlate well with pulmonary symptoms in patients with childhood onset SLE, they nevertheless provide objective quantification of the type and severity of the functional lesions.

AB - Objectives: The aim of this study was to investigate the frequency of pulmonary function abnormalities in clinically asymptomatic children with Systemic Lupus Erythematosus and to determine the relationship of these abnormalities to clinical, laboratory, and immunological parameters as well as to disease activity. Methods: Forty-two children with childhood onset Systemic Lupus Erythematosus were included in this study. Demographic, clinical, laboratory and immunological parameters, as well as disease activity were assessed. Pulmonary function tests (PFT) were performed routinely to screen for subclinical lung disease. Results: Out of the 42 children, 19% (n=8) had clinical evidence of pulmonary involvement. The patients with no clinical evidence of pulmonary involvement (n=34) represent the study cohort. From our cohort of patients with no clinical evidence of pulmonary involvement 79% (n=27) had PFT abnormality; including 62% (n=21) had reduced FVC, 71% (n=24) had reduced FEV1, and 67% (n=12) had reduced DLCO. Similarly, 56% (n=15) had a restrictive PFT pattern, and 2.6% (n=2) had an obstructive PFT pattern, while 33% (n=7) had an isolated impairment of diffusion capacity. Due to small sample size; it was not possible to find a statistically significant difference between the cohort of asymptomatic SLE patients with abnormal PFT findings (n=27) and those with normal PFT findings (n=7) in terms of clinical, laboratory, immunological or disease activity index score. Conclusion: Subclinical lung disease, as demonstrated by abnormal PFT in patients with normal radiographs, may be common but should be interpreted with caution as an early sign of lung disease. Although PFT studies do not correlate well with pulmonary symptoms in patients with childhood onset SLE, they nevertheless provide objective quantification of the type and severity of the functional lesions.

KW - Oman

KW - Prevalence

KW - Pulmonary

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=84857466822&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857466822&partnerID=8YFLogxK

U2 - 10.5001/omj.2012.07

DO - 10.5001/omj.2012.07

M3 - Article

C2 - 22359723

AN - SCOPUS:84857466822

VL - 27

SP - 36

EP - 39

JO - Oman Medical Journal

JF - Oman Medical Journal

SN - 1999-768X

IS - 1

ER -