Expression of the oxytocin gene, but not the vasopressin gene, in the rat uterus during pregnancy: Influence of oestradiol and progesterone

Thomas Bossmar, N. Osman, E. Zilahi, M. A. El Haj, N. Nowotny, J. M. Conlon

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7 Citations (Scopus)

Abstract

Oxytocin (OT) and vasopressin (VP) are neurohypophyseal hormones with potent stimulatory actions on the uterus. In order to determine whether these hormones may have a paracrine action on the uterus, OT and VP gene expression was studied in myometrium from pregnant rats at gestational ages of 14 and 20 days, and from ovariectomized animals treated with oestradiol and progesterone. OT and VP mRNA concentrations were measured using real-time quantitative reverse transcription-PCR, and OT- and VP-like immunoreactivities were determined using RIA. OT mRNA was detected in the uterus from pregnant rats, but did not differ between the groups of different gestational ages. Oestradiol significantly (P

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalJournal of Endocrinology
Volume193
Issue number1
DOIs
Publication statusPublished - Apr 2007

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ASJC Scopus subject areas

  • Endocrinology

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