TY - JOUR
T1 - Expression levels of β-catenin and galectin-3 in meningioma and their effect on brain invasion and recurrence
T2 - a tissue microarray study
AU - Ahmed, Rehab Allah
AU - Shebl, Abdelhadi M.
AU - Habashy, Hany Onsy
N1 - Publisher Copyright:
Copyright © 2017 by Cancer Biology & Medicine.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Objective: Meningiomas are neoplasms that arise from the meninges of the central nervous system (CNS). They constitute about 25.6% of CNS tumors diagnosed in Egypt. Some morphological variants of meningiomas display aggressive behavior, leading to brain-invasive growth pattern. Although meningiomas are usually treated by complete surgical excision, the risk of postoperative recurrence remains. Hence, additional biomarkers for predicting aggressive behavior must be discovered. This study aims to explore the clinical and biological relevance of the protein expression levels of β-catenin and galectine-3 in meningioma and to understand the pathobiology of this neoplasm. Methods: This retrospective study was carried out on 153 cases of meningioma by using tissue microarrays and immunohistochemistry for β-catenin and galectine-3. Results: High β-catenin expression was significantly associated with transitional and meningiotheliomatous meningiomas, low tumor grade, low recurrence rate, and low incidence of brain invasion. Meanwhile, high galectin-3 expression was associated with brain invasion, recurrence, high tumor grade, and tumor type. Logistic regression analysis indicated that among all variables included in the model, β-catenin and galactin-3 expression levels were significant predictors of tumor recurrence (P<0.001). Conclusions: Galectin-3 and β-catenin are involved in meningioma recurrence but not in brain invasion. These molecules could be important potential therapeutic targets and predictors for meningiomas.
AB - Objective: Meningiomas are neoplasms that arise from the meninges of the central nervous system (CNS). They constitute about 25.6% of CNS tumors diagnosed in Egypt. Some morphological variants of meningiomas display aggressive behavior, leading to brain-invasive growth pattern. Although meningiomas are usually treated by complete surgical excision, the risk of postoperative recurrence remains. Hence, additional biomarkers for predicting aggressive behavior must be discovered. This study aims to explore the clinical and biological relevance of the protein expression levels of β-catenin and galectine-3 in meningioma and to understand the pathobiology of this neoplasm. Methods: This retrospective study was carried out on 153 cases of meningioma by using tissue microarrays and immunohistochemistry for β-catenin and galectine-3. Results: High β-catenin expression was significantly associated with transitional and meningiotheliomatous meningiomas, low tumor grade, low recurrence rate, and low incidence of brain invasion. Meanwhile, high galectin-3 expression was associated with brain invasion, recurrence, high tumor grade, and tumor type. Logistic regression analysis indicated that among all variables included in the model, β-catenin and galactin-3 expression levels were significant predictors of tumor recurrence (P<0.001). Conclusions: Galectin-3 and β-catenin are involved in meningioma recurrence but not in brain invasion. These molecules could be important potential therapeutic targets and predictors for meningiomas.
KW - Brain invasion
KW - Galectin-3 and β-catenin
KW - Immunohistochemistry
KW - Meningioma
KW - Recurrence
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U2 - 10.20892/j.issn.2095-3941.2017.0024
DO - 10.20892/j.issn.2095-3941.2017.0024
M3 - Article
AN - SCOPUS:85028538522
SN - 2095-3941
VL - 14
SP - 319
EP - 326
JO - Cancer Biology and Medicine
JF - Cancer Biology and Medicine
IS - 3
ER -