Experience of intravitreal triamcinolone acetonide for treatment of diabetic macular edema among Omani population

Ahmed Al Hinai, Upender Krishen Wali, Tayseer Abdul Rasool, Syed G. Rizvi

Research output: Contribution to journalArticle

Abstract

PURPOSE: The purpose of this study was to evaluate the outcome of intravitreal (IVT) triamcinolone in diabetic macular edema (DME). MATERIALS AND METHODS: A retrospective study of 42 eyes diagnosed clinically and supported with optical coherence tomography (OCT), with DME of more than 300 μm in thickness. All eyes were injected with a single IVT injection of preservative free triamcinolone acetonide (TA) with dose of 4 mg. Patients were subjected to visual acuity (VA) and OCT on each follow-up visit which was continued for 6 months. The total number of IVT injections given was 48. Six eyes had a repeat injection. None of the eyes had any other IVT injection within 6 weeks of TA. Twenty-one eyes were pseudophakic. RESULTS: Mean age of the patients was 58.8 years. The mean central subfield thickness (CST) at baseline was 504.6 μm. At 6 weeks, the mean CST dropped by 183.6 μm (P < 0.00001). At 6-month follow-up, the mean CST had increased by 74.6 μm from 6 weeks level; however, the 6-month mean CST was 109 μ less than mean baseline thickness (P < 0.0005). The mean baseline VA was 0.80 LogMAR units. At 6 weeks, the mean VA dropped by 0.01 LogMAR. At 6 months, VA improved by 0.02 LogMAR units from baseline. Overall, VA improved in 47% eyes, dropped from baseline in 35% eyes, and remained unchanged in 18% eyes. CONCLUSION: Triamcinolone acetonide is a safe, effective, and promising therapy in DME.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalOman Journal of Ophthalmology
Volume10
Issue number3
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • Diabetic macular edema
  • optical coherence tomography
  • triamcinolone acetonide
  • visual acuity

ASJC Scopus subject areas

  • Ophthalmology

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