Exercise protects against insulin-dependent diabetes-induced osteoarthritis in rats: A scanning electron microscopy study

Fahaid Al-Hashem, Abbas O. El Karib, Ismaeel Bin-Jaliah, Mohammad Dallak, Hussein F. Sakr, Refaat A. Eid, Mohamed Samir A. Zaki, Mariam Al-Shamsi, Mohamed A. Haidara, Bahjat Al-Ani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We tested the hypothesis that swim exercise can protect the articular cartilage from damages induced secondary to insulin-dependent diabetes mellitus in rats using the scanning electron microscopy and to monitor the blood levels of oxidative and antioxidative stress biomarkers that are known to be modulated in osteoarthritis (OA). A profound damage to the cartilage was observed in the diabetic rats. Our findings also show that swim exercise protects the knee joints from damage induced by diabetes as well as significantly inhibiting OA-induced upregulation of thiobarbituric acid reactive substances (TBARS) and tumor necrosis factor alpha (TNF-α) and augmented superoxide dismutase (SOD) inhibition by OA. Thus, we demonstrated an effective protection by swim exercise against diabetes-induced OA in a rat model of the disease.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalUltrastructural Pathology
Volume41
Issue number3
DOIs
Publication statusPublished - May 4 2017

Fingerprint

Osteoarthritis
Electron Scanning Microscopy
Insulin
Thiobarbituric Acid Reactive Substances
Articular Cartilage
Knee Joint
Type 1 Diabetes Mellitus
Superoxide Dismutase
Cartilage
Oxidative Stress
Up-Regulation
Tumor Necrosis Factor-alpha
Biomarkers

Keywords

  • Articular cartilage
  • diabetes
  • osteoarthritis
  • rat model
  • swim exercise

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

Cite this

Exercise protects against insulin-dependent diabetes-induced osteoarthritis in rats : A scanning electron microscopy study. / Al-Hashem, Fahaid; El Karib, Abbas O.; Bin-Jaliah, Ismaeel; Dallak, Mohammad; Sakr, Hussein F.; Eid, Refaat A.; Zaki, Mohamed Samir A.; Al-Shamsi, Mariam; Haidara, Mohamed A.; Al-Ani, Bahjat.

In: Ultrastructural Pathology, Vol. 41, No. 3, 04.05.2017, p. 252-257.

Research output: Contribution to journalArticle

Al-Hashem, F, El Karib, AO, Bin-Jaliah, I, Dallak, M, Sakr, HF, Eid, RA, Zaki, MSA, Al-Shamsi, M, Haidara, MA & Al-Ani, B 2017, 'Exercise protects against insulin-dependent diabetes-induced osteoarthritis in rats: A scanning electron microscopy study', Ultrastructural Pathology, vol. 41, no. 3, pp. 252-257. https://doi.org/10.1080/01913123.2017.1313346
Al-Hashem, Fahaid ; El Karib, Abbas O. ; Bin-Jaliah, Ismaeel ; Dallak, Mohammad ; Sakr, Hussein F. ; Eid, Refaat A. ; Zaki, Mohamed Samir A. ; Al-Shamsi, Mariam ; Haidara, Mohamed A. ; Al-Ani, Bahjat. / Exercise protects against insulin-dependent diabetes-induced osteoarthritis in rats : A scanning electron microscopy study. In: Ultrastructural Pathology. 2017 ; Vol. 41, No. 3. pp. 252-257.
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