Exercise protects against insulin-dependent diabetes-induced osteoarthritis in rats: A scanning electron microscopy study

Fahaid Al-Hashem, Abbas O. El Karib, Ismaeel Bin-Jaliah, Mohammad Dallak, Hussein F. Sakr, Refaat A. Eid, Mohamed Samir A. Zaki, Mariam Al-Shamsi, Mohamed A. Haidara, Bahjat Al-Ani

Research output: Contribution to journalArticle

5 Citations (Scopus)


We tested the hypothesis that swim exercise can protect the articular cartilage from damages induced secondary to insulin-dependent diabetes mellitus in rats using the scanning electron microscopy and to monitor the blood levels of oxidative and antioxidative stress biomarkers that are known to be modulated in osteoarthritis (OA). A profound damage to the cartilage was observed in the diabetic rats. Our findings also show that swim exercise protects the knee joints from damage induced by diabetes as well as significantly inhibiting OA-induced upregulation of thiobarbituric acid reactive substances (TBARS) and tumor necrosis factor alpha (TNF-α) and augmented superoxide dismutase (SOD) inhibition by OA. Thus, we demonstrated an effective protection by swim exercise against diabetes-induced OA in a rat model of the disease.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalUltrastructural Pathology
Issue number3
Publication statusPublished - May 4 2017



  • Articular cartilage
  • diabetes
  • osteoarthritis
  • rat model
  • swim exercise

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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