Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension

Abderrahim Nemmar, Shaheen Zia, Deepa Subramaniyan, Mohamed A. Fahim, Badreldin H. Ali

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study was undertaken to determine the cardiovascular effect of diesel exhaust on TO mice made hypertensive by implanting osmotic minipump infusing angiotensin II or vehicle (control). On day 13, the animals were intratracheally instilled with either DEP (15μg/mouse) or saline. 24h later, pulmonary exposure to DEP had significantly decreased the systolic blood pressure (SBP) in hypertensive (HT) mice (P2 was decreased, and PaCO2 increased in DEP-treated HT mice compared to NT mice treated with DEP (P

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalToxicology
Volume285
Issue number1-2
DOIs
Publication statusPublished - Jul 11 2011

Keywords

  • Air pollution
  • Diesel exhaust particles
  • Hypertension
  • Thrombosis

ASJC Scopus subject areas

  • Toxicology

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