Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension

Abderrahim Nemmar; Shaheen Zia; Deepa Subramaniyan; Mohamed A. Fahim; Badreldin H. Ali

doi:10.1016/j.tox.2011.03.018

Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension

Abderrahim Nemmar^*, Shaheen Zia, Deepa Subramaniyan, Mohamed A. Fahim, Badreldin H. Ali

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study was undertaken to determine the cardiovascular effect of diesel exhaust on TO mice made hypertensive by implanting osmotic minipump infusing angiotensin II or vehicle (control). On day 13, the animals were intratracheally instilled with either DEP (15μg/mouse) or saline. 24h later, pulmonary exposure to DEP had significantly decreased the systolic blood pressure (SBP) in hypertensive (HT) mice (P2 was decreased, and PaCO₂ increased in DEP-treated HT mice compared to NT mice treated with DEP (P

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Toxicology
Volume	285
Issue number	1-2
DOIs	https://doi.org/10.1016/j.tox.2011.03.018
Publication status	Published - Jul 11 2011

Keywords

Air pollution
Diesel exhaust particles
Hypertension
Thrombosis

ASJC Scopus subject areas

Toxicology

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10.1016/j.tox.2011.03.018

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abstract = "Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study was undertaken to determine the cardiovascular effect of diesel exhaust on TO mice made hypertensive by implanting osmotic minipump infusing angiotensin II or vehicle (control). On day 13, the animals were intratracheally instilled with either DEP (15μg/mouse) or saline. 24h later, pulmonary exposure to DEP had significantly decreased the systolic blood pressure (SBP) in hypertensive (HT) mice (P2 was decreased, and PaCO2 increased in DEP-treated HT mice compared to NT mice treated with DEP (P",

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