TY - JOUR
T1 - Evaluation of phytochemical, antioxidant and anti-inflammatory properties of near endemic aloe dhufarensis
AU - Sherwaniq, Neelam
AU - Al Mahroqi, Khalil
AU - Farooq, Sardar A.
N1 - Publisher Copyright:
© 2021 Neelam Sherwani et al.
PY - 2021
Y1 - 2021
N2 - Background and Objective: Aloe dhufarensis is a local endemic medicinal herb used for centuries to treat diabetes, headache, fever, skin disorders and wound healing by the local people of Oman. The present research was initiated to substantiate the ethno-medicinal uses of this plant by assessing the phytochemicals and evaluating the antioxidant, anti-inflammatory and anti-microbial activity of Aloe dhufarensis. Materials and Methods: Dried, finely grinded leaves of A. dhufarensis were extracted with methanol for phytochemical analysis using standard protocols and several phytochemical such as saponins, alkaloids, terpenoids, flavonoids, steroids, tannins, glycosides, anthraquinones, phytosterol, coumarins and carbohydrates were detected in the extract. Results: Extracts displayed significant antioxidant property, exhibiting a potent DPPH scavenging activity with IC50 value of 83.46 μg mLG1 and a strong hydrogen peroxide scavenging activity with an IC50 value of 289.786 μg mLG1. Substantial inhibition of protein denaturation and anti-proteinase activity were recorded. Considerable antibacterial activity was observed against all 4 studied strains with the highest antibacterial activity recorded against the E. coli. Conclusion: The results reveal that A. dhufarensis possess a wide spectrum of phytochemicals that have significant pharmacological properties and substantiate the support to the scientific basis for the traditional use of this ethnomedicinal herb.
AB - Background and Objective: Aloe dhufarensis is a local endemic medicinal herb used for centuries to treat diabetes, headache, fever, skin disorders and wound healing by the local people of Oman. The present research was initiated to substantiate the ethno-medicinal uses of this plant by assessing the phytochemicals and evaluating the antioxidant, anti-inflammatory and anti-microbial activity of Aloe dhufarensis. Materials and Methods: Dried, finely grinded leaves of A. dhufarensis were extracted with methanol for phytochemical analysis using standard protocols and several phytochemical such as saponins, alkaloids, terpenoids, flavonoids, steroids, tannins, glycosides, anthraquinones, phytosterol, coumarins and carbohydrates were detected in the extract. Results: Extracts displayed significant antioxidant property, exhibiting a potent DPPH scavenging activity with IC50 value of 83.46 μg mLG1 and a strong hydrogen peroxide scavenging activity with an IC50 value of 289.786 μg mLG1. Substantial inhibition of protein denaturation and anti-proteinase activity were recorded. Considerable antibacterial activity was observed against all 4 studied strains with the highest antibacterial activity recorded against the E. coli. Conclusion: The results reveal that A. dhufarensis possess a wide spectrum of phytochemicals that have significant pharmacological properties and substantiate the support to the scientific basis for the traditional use of this ethnomedicinal herb.
KW - Aloe dhufarensis
KW - Anti-inflammatory
KW - Anti-oxidant
KW - Phytochemical analysis
KW - Total phenols
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U2 - 10.3923/ajps.2021.332.343
DO - 10.3923/ajps.2021.332.343
M3 - Article
AN - SCOPUS:85103653620
SN - 1682-3974
VL - 20
SP - 332
EP - 343
JO - Asian Journal of Plant Sciences
JF - Asian Journal of Plant Sciences
IS - 2
ER -