TY - JOUR
T1 - Ethanol-induced alteration in thiamin status of young turkey poults
AU - Ali, Badreldin H.
AU - Czarnecki, Caroline M.
N1 - Funding Information:
Acknowledgements--The authors are grateful to Mark Pessin who provided such excellent care of the poults, Mr Carl W. Edborg III, who furnished and prepared the poultry housing facilities and the Dale Peterson Turkey Hatchery, Cannon Falls, Minnesota for the generous supply of poults. This investigation was supported by a grant from the
PY - 1987
Y1 - 1987
N2 - 1. 1. The effect of ethanol on thiamin status was determined in the turkey poult, a new animal model for alcohol-induced cardiomyopathy in humans. 2. 2. The poults were given ethanol (4 to 5% v/v) in the drinking water for six weeks post-hatch. This treatment decreased body weights and increased significantly the relative weights of the hearts. 3. 3. Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect). 4. 4. These findings indicate that ethanol treatment has an adverse effect on the thiamin status of the turkey poult.
AB - 1. 1. The effect of ethanol on thiamin status was determined in the turkey poult, a new animal model for alcohol-induced cardiomyopathy in humans. 2. 2. The poults were given ethanol (4 to 5% v/v) in the drinking water for six weeks post-hatch. This treatment decreased body weights and increased significantly the relative weights of the hearts. 3. 3. Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect). 4. 4. These findings indicate that ethanol treatment has an adverse effect on the thiamin status of the turkey poult.
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U2 - 10.1016/0306-3623(87)90236-9
DO - 10.1016/0306-3623(87)90236-9
M3 - Article
C2 - 3569840
AN - SCOPUS:0023094101
SN - 0306-3623
VL - 18
SP - 119
EP - 121
JO - General Pharmacology
JF - General Pharmacology
IS - 2
ER -