Abstract
1. 1. The effect of ethanol on thiamin status was determined in the turkey poult, a new animal model for alcohol-induced cardiomyopathy in humans. 2. 2. The poults were given ethanol (4 to 5% v/v) in the drinking water for six weeks post-hatch. This treatment decreased body weights and increased significantly the relative weights of the hearts. 3. 3. Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect). 4. 4. These findings indicate that ethanol treatment has an adverse effect on the thiamin status of the turkey poult.
| Original language | English |
|---|---|
| Pages (from-to) | 119-121 |
| Number of pages | 3 |
| Journal | General Pharmacology |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1987 |
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ASJC Scopus subject areas
- Pharmacology
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Ethanol-induced alteration in thiamin status of young turkey poults. / Ali, Badreldin H.; Czarnecki, Caroline M.
In: General Pharmacology, Vol. 18, No. 2, 1987, p. 119-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ethanol-induced alteration in thiamin status of young turkey poults
AU - Ali, Badreldin H.
AU - Czarnecki, Caroline M.
PY - 1987
Y1 - 1987
N2 - 1. 1. The effect of ethanol on thiamin status was determined in the turkey poult, a new animal model for alcohol-induced cardiomyopathy in humans. 2. 2. The poults were given ethanol (4 to 5% v/v) in the drinking water for six weeks post-hatch. This treatment decreased body weights and increased significantly the relative weights of the hearts. 3. 3. Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect). 4. 4. These findings indicate that ethanol treatment has an adverse effect on the thiamin status of the turkey poult.
AB - 1. 1. The effect of ethanol on thiamin status was determined in the turkey poult, a new animal model for alcohol-induced cardiomyopathy in humans. 2. 2. The poults were given ethanol (4 to 5% v/v) in the drinking water for six weeks post-hatch. This treatment decreased body weights and increased significantly the relative weights of the hearts. 3. 3. Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect). 4. 4. These findings indicate that ethanol treatment has an adverse effect on the thiamin status of the turkey poult.
UR - http://www.scopus.com/inward/record.url?scp=0023094101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023094101&partnerID=8YFLogxK
U2 - 10.1016/0306-3623(87)90236-9
DO - 10.1016/0306-3623(87)90236-9
M3 - Article
VL - 18
SP - 119
EP - 121
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 2
ER -