Abstract
Chronic kidney disease (CKD) is an important epidemic and public health problem that is associated with a significant risk for vascular disease and early cardiovascular mortality as well as progression of kidney disease. Currently it is classified into five stages based on the glomerular filtration rate (GFR) as recommended by many professional guidelines. Radiolabelled methods for measuring GFR are accurate but not practical and can be used only on a very limited scale while the traditional methods require timed urine collection with its drawback of inaccuracy, cumbersomeness and inconvenience for the patients. However, the development of formulabased calculation of estimated GFR (eGFR) has offered a very practical and easy approach for converting serum creatinine value into GFR result taking into consideration patient's age, sex, ethnicity and weight (depending on equation type). The commonly used equations include Cockraft and Gault (1976), Modification of Diet in Renal Disease (MDRD) (1999) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (2009). It is the implementation of these equations particularly the MDRD that has raised the medical awareness in the diagnosis and management of CKD and its adoption by many guidelines in North America and Europe. The impact and pitfalls of each of these equations in the screening, diagnosis and management of patients with CKD are presented and discussed in this review.
| Original language | English |
|---|---|
| Pages (from-to) | 108-113 |
| Number of pages | 6 |
| Journal | Oman Medical Journal |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Chronic kidney disease
- CKD-EPI
- Cockraft and gault
- eGFR
- MDRD
ASJC Scopus subject areas
- Medicine(all)
Cite this
Estimated glomerular filtration rate (eGFR) : A serum creatinine-based test for the detection of chronic kidney disease and its impact on clinical practice. / Mula-Abed, Waad Allah S; Al Rasadi, Khalid; Al-Riyami, Dawood.
In: Oman Medical Journal, Vol. 27, No. 2, 2012, p. 108-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estimated glomerular filtration rate (eGFR)
T2 - A serum creatinine-based test for the detection of chronic kidney disease and its impact on clinical practice
AU - Mula-Abed, Waad Allah S
AU - Al Rasadi, Khalid
AU - Al-Riyami, Dawood
PY - 2012
Y1 - 2012
N2 - Chronic kidney disease (CKD) is an important epidemic and public health problem that is associated with a significant risk for vascular disease and early cardiovascular mortality as well as progression of kidney disease. Currently it is classified into five stages based on the glomerular filtration rate (GFR) as recommended by many professional guidelines. Radiolabelled methods for measuring GFR are accurate but not practical and can be used only on a very limited scale while the traditional methods require timed urine collection with its drawback of inaccuracy, cumbersomeness and inconvenience for the patients. However, the development of formulabased calculation of estimated GFR (eGFR) has offered a very practical and easy approach for converting serum creatinine value into GFR result taking into consideration patient's age, sex, ethnicity and weight (depending on equation type). The commonly used equations include Cockraft and Gault (1976), Modification of Diet in Renal Disease (MDRD) (1999) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (2009). It is the implementation of these equations particularly the MDRD that has raised the medical awareness in the diagnosis and management of CKD and its adoption by many guidelines in North America and Europe. The impact and pitfalls of each of these equations in the screening, diagnosis and management of patients with CKD are presented and discussed in this review.
AB - Chronic kidney disease (CKD) is an important epidemic and public health problem that is associated with a significant risk for vascular disease and early cardiovascular mortality as well as progression of kidney disease. Currently it is classified into five stages based on the glomerular filtration rate (GFR) as recommended by many professional guidelines. Radiolabelled methods for measuring GFR are accurate but not practical and can be used only on a very limited scale while the traditional methods require timed urine collection with its drawback of inaccuracy, cumbersomeness and inconvenience for the patients. However, the development of formulabased calculation of estimated GFR (eGFR) has offered a very practical and easy approach for converting serum creatinine value into GFR result taking into consideration patient's age, sex, ethnicity and weight (depending on equation type). The commonly used equations include Cockraft and Gault (1976), Modification of Diet in Renal Disease (MDRD) (1999) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (2009). It is the implementation of these equations particularly the MDRD that has raised the medical awareness in the diagnosis and management of CKD and its adoption by many guidelines in North America and Europe. The impact and pitfalls of each of these equations in the screening, diagnosis and management of patients with CKD are presented and discussed in this review.
KW - Chronic kidney disease
KW - CKD-EPI
KW - Cockraft and gault
KW - eGFR
KW - MDRD
UR - http://www.scopus.com/inward/record.url?scp=84859183491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859183491&partnerID=8YFLogxK
U2 - 10. 5001/omj.2012.23
DO - 10. 5001/omj.2012.23
M3 - Article
VL - 27
SP - 108
EP - 113
JO - Oman Medical Journal
JF - Oman Medical Journal
SN - 1999-768X
IS - 2
ER -