ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor

Nurhayati H. Munawer, Reena Md Zin, Siti Aishah Md Ali*, Rohaizak Muhammad, Jasmi Ali, Srijit Das

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Fibroadenomas (FA) are common while phyllodes tumors (PT) are rare and both tumors are composed of epithelial and stromal components. We evaluated the expression status of ER, Bcl2, p53, and MIB-1 protein in these tumors. Methods: One hundred and ninety-three tumors comprising of 117 FAs and 76 PTs were examined using immunohistochemistry on tissue microarray. Results: The mean age of patients with FA was 28.5 years while the mean ages of patients with benign, borderline and malignant PTs were 41.7, 48.6 and 42.1 years, respectively. Also all types of PTs were large (>5cm). ER showed a strong nuclear staining in the epithelial component of all tumors while ERβimmunoreactivity was detected in both the epithelial and stromal components of FA and PT. ERβ(p<0.001), and p53 (p=0.006) in the stromal component were associated with tumor size. p53 expression was significantly associated with both the epithelial and stromal components of malignant PTs (p<0.05). In the PT, the decreased expressions of p53 and MIB-1 were significantly different with positive Bcl2 protein expression in the epithelial component (p=0.000). In addition, MIB-1 was also found to be associated with ER and ERβin the stromal component (p=0.000). Conclusions: The expression of p53 with tumor size and histological grade in PT may increase the risk for malignancy.

Original languageEnglish
Pages (from-to)486-492
Number of pages7
JournalBiomedical Journal
Volume35
Issue number6
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Keywords

  • estrogen receptor
  • fibroadenoma
  • immunohistochemistry
  • MIB-1 protein
  • p53 antigen
  • phyllodes tu-mor

ASJC Scopus subject areas

  • Medicine(all)

Cite this