Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) of the orbit

A case report

Bruno F. Fernandes, Abdullah Al-Mujaini, Tina Petrogiannis-Haliotis, Abdullah Al-Kandari, Bryan Arthurs, Miguel N. Burnier

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's Disease (KD) share many clinical and histopathological features. Although they were once considered different stages of the same disease, they are now known to represent separate entities. Recently, ALHE is being called epithelioid hemangioma (EH), a term that better describes the possible neoplastic nature of the entity. Case Presentation: An eighteen year-old Asian female presented with a three-month history of fluctuating swelling and ptosis of the left upper eyelid. Computed tomography disclosed a distinct homogeneous lesion in the left superior orbit, molding to the globe and other orbital structures. At histopathological evaluation the lesion was composed of numerous blood vessels lined by plump endothelial cells with oval nuclei protruding into the lumen. Surrounding the vessels, there was a chronic inflammatory infiltrate with a large proportion of eosinophils. Based on clinical and histopathological findings, the diagnosis of EH was made. Conclusion: Although exams like blood count, urinalysis and whole body scans can assist in the differential diagnosis, EH can be diagnosed and differentiated from KD on histopathological grounds. The presence of vascular hyperplasia with plump endothelial cells protruding into the lumen is the most important discriminator in establishing the diagnosis of EH. Such distinction is crucial for the patient because EH is not associated with any of the systemic manifestations present in KD.

Original languageEnglish
Article number30
JournalJournal of Medical Case Reports
Volume1
DOIs
Publication statusPublished - Jun 25 2007

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Angiolymphoid Hyperplasia with Eosinophilia
Orbit
Hemangioma
Blood Vessels
Endothelial Cells
Whole Body Imaging
Urinalysis
Eyelids
Eosinophils
Hyperplasia
Differential Diagnosis
Tomography

ASJC Scopus subject areas

  • Medicine(all)

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Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) of the orbit : A case report. / Fernandes, Bruno F.; Al-Mujaini, Abdullah; Petrogiannis-Haliotis, Tina; Al-Kandari, Abdullah; Arthurs, Bryan; Burnier, Miguel N.

In: Journal of Medical Case Reports, Vol. 1, 30, 25.06.2007.

Research output: Contribution to journalArticle

Fernandes, Bruno F. ; Al-Mujaini, Abdullah ; Petrogiannis-Haliotis, Tina ; Al-Kandari, Abdullah ; Arthurs, Bryan ; Burnier, Miguel N. / Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) of the orbit : A case report. In: Journal of Medical Case Reports. 2007 ; Vol. 1.
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