Epidemiology of chronic hepatitis C infections at a tertiary care centre in Oman

Said A. Al-Busafi, Halima Al-Shuaili, Heba Omar, Haifa Al-Zuhaibi, L. Jeyaseelan, Khalid Al-Naamani

Research output: Contribution to journalArticle

Abstract

Objectives: Chronic hepatitis C (CHC) is a leading cause of liver cirrhosis and hepatocellular carcinoma (HCC) worldwide. However, there is a lack of data regarding the epidemiology of CHC in Oman. This study aimed to describe the clinicopathological characteristics and outcomes of CHC-infected patients at a tertiary care hospital in Oman. Methods: This retrospective descriptive hospital-based study included all CHC-infected patients who presented to the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman, between January 2010 and December 2015. The baseline demographic, clinical, laboratory and radiological data of the patients were analysed. Results: A total of 603 CHC-infected patients were identified during the study period; of these, 65.8% were male and the mean age was 44.8 ± 16.5 years. The main risk factors associated with CHC infection were intravenous drug abuse (23.9%) and a history of blood transfusions (20.7%). The most prevalent virus genotypes were 1 and 3 (44.0% and 35.1%, respectively). Upon initial presentation, 33.0% of the cohort had liver cirrhosis; of these, 48.7% had decompensated cirrhosis and 23.1% had HCCs. Liver transplantation was only performed for 7.5% of the cirrhosis patients, mostly as a curative treatment for HCC. Conclusion: The implementation of national policies to prevent hepatitis C transmission and encourage the early screening of at-risk patients is recommended to reduce the burden and consequences of this disease in Oman.

Original languageEnglish
Pages (from-to)e404-e410
JournalSultan Qaboos University Medical Journal
Volume17
Issue number4
DOIs
Publication statusPublished - Nov 1 2017

Fingerprint

Oman
Chronic Hepatitis C
Tertiary Care Centers
Epidemiology
Infection
Liver Cirrhosis
Hepatocellular Carcinoma
Fibrosis
Intravenous Substance Abuse
Tertiary Healthcare
Hepatitis C
Blood Transfusion
Liver Transplantation
Genotype
Demography
Viruses

Keywords

  • Chronic hepatitis C
  • Genotypes
  • Hepatocellular carcinoma
  • Infectious disease transmission
  • Liver cirrhosis
  • Oman

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Epidemiology of chronic hepatitis C infections at a tertiary care centre in Oman. / Al-Busafi, Said A.; Al-Shuaili, Halima; Omar, Heba; Al-Zuhaibi, Haifa; Jeyaseelan, L.; Al-Naamani, Khalid.

In: Sultan Qaboos University Medical Journal, Vol. 17, No. 4, 01.11.2017, p. e404-e410.

Research output: Contribution to journalArticle

Al-Busafi, Said A. ; Al-Shuaili, Halima ; Omar, Heba ; Al-Zuhaibi, Haifa ; Jeyaseelan, L. ; Al-Naamani, Khalid. / Epidemiology of chronic hepatitis C infections at a tertiary care centre in Oman. In: Sultan Qaboos University Medical Journal. 2017 ; Vol. 17, No. 4. pp. e404-e410.
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abstract = "Objectives: Chronic hepatitis C (CHC) is a leading cause of liver cirrhosis and hepatocellular carcinoma (HCC) worldwide. However, there is a lack of data regarding the epidemiology of CHC in Oman. This study aimed to describe the clinicopathological characteristics and outcomes of CHC-infected patients at a tertiary care hospital in Oman. Methods: This retrospective descriptive hospital-based study included all CHC-infected patients who presented to the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman, between January 2010 and December 2015. The baseline demographic, clinical, laboratory and radiological data of the patients were analysed. Results: A total of 603 CHC-infected patients were identified during the study period; of these, 65.8{\%} were male and the mean age was 44.8 ± 16.5 years. The main risk factors associated with CHC infection were intravenous drug abuse (23.9{\%}) and a history of blood transfusions (20.7{\%}). The most prevalent virus genotypes were 1 and 3 (44.0{\%} and 35.1{\%}, respectively). Upon initial presentation, 33.0{\%} of the cohort had liver cirrhosis; of these, 48.7{\%} had decompensated cirrhosis and 23.1{\%} had HCCs. Liver transplantation was only performed for 7.5{\%} of the cirrhosis patients, mostly as a curative treatment for HCC. Conclusion: The implementation of national policies to prevent hepatitis C transmission and encourage the early screening of at-risk patients is recommended to reduce the burden and consequences of this disease in Oman.",
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