Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations

Ralf Dürrwald, Jolanta Kolodziejek, Aemero Muluneh, Sibylle Herzog, Norbert Nowotny

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44 Citations (Scopus)


Classical Borna disease (cBD), a nonpurulent encephalitis of solipeds and sheep, is endemic in certain areas of central Europe. The etiologic agent is Borna disease virus (BDV), thus far the only member of the family Bornaviridae. Based on epidemiological patterns of cBD and recent phylogenetic findings this review hypothesizes the possible existence of yet unknown BDV reservoir host populations, and analyzes critically BDVs from outside endemic regions.

Original languageEnglish
Pages (from-to)917-929
Number of pages13
JournalMicrobes and Infection
Issue number3
Publication statusPublished - Mar 2006



  • Borna disease virus
  • Epidemiological pattern
  • Etiology
  • Genetic clustering
  • Reservoir host population

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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