Ependymoma with extensive lipidization mimicking adipose tissue: A report of five cases

Mehar Chand Sharma, Rina Arora, Ritu Lakhtakia, Ashok Kumar Mahapatra, Chitra Sarkar

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31 Citations (Scopus)

Abstract

Lipomatous ependymoma is a recently described entity and only 3 cases of this variant have been reported in the literature. We report 5 cases of this rare variant of ependymoma. Patients' age ranged from 4 years to 45 years and, interestingly, all of them were males. Two tumors were supratentorial in location, 2 in the fourth ventricle and 1 was intramedullary. Microscopically all of them showed the classical histology of ependymoma along with lipomatous differentiation. The lipomatous component was composed of cells with a large clear vacuole pushing the nucleus to the periphery and giving a signet ring cell appearance. This component demonstrated positivity for GFAP and S-100 protein thereby confirming its glial lineage. Three of the 5 tumors were high grade (WHO-grade III), had a high MIB-1 labelling index (MIB-1 LI) and showed recurrence on follow-up. However, 2 were low grade (WHO grade II) and patients are free of disease till the last follow up.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalPathology and Oncology Research
Volume6
Issue number2
Publication statusPublished - 2000

Keywords

  • Adipocyte
  • Ependymoma
  • Intracranial tumor
  • Lipomatous change
  • Metaplasia
  • Signet ring cell

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

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  • Cite this

    Sharma, M. C., Arora, R., Lakhtakia, R., Mahapatra, A. K., & Sarkar, C. (2000). Ependymoma with extensive lipidization mimicking adipose tissue: A report of five cases. Pathology and Oncology Research, 6(2), 136-140.