Encapsulation and Release of Moxifloxacin Hydrochloride in Chitosan-Dextran Sulphate Microcapsules

M. Geetha Devi, Susmita Dutta, Ashraf Talib Al Hinai, S. Feroz

Research output: Contribution to journalArticle

Abstract

In the present work, multilayer microcapsules of size 350 nm were prepared with layer-by-layer assembly of oppositely charged chitosan and dextran sulphate on silica template. The monodisperse silica particles (310 nm) with fine spherical shape were successfully synthesized by Stober's method. Dissolution of silica particles in HF leads to the formation of hollow capsules. The resulting capsules were found to be able to effectively load moxifloxacin hydrochloride in the interior of the capsules under modest conditions without addition of other reagents, as demonstrated by scanning electron microscopy. Parameters affecting loading and release such as pH and initial concentrations were investigated. Release studies were performed in in-vitro mode with a semi-automatic release protocol, with different pH solutions in water and phosphate buffered saline. The size of silica particles was analysed by dynamic light scattering method. Scanning electron microscopy and energy dispersive X-ray spectroscopy measurements proved the surface morphology and purity of the hollow capsules from the core material. The kinetics of drug release mechanism was studied using Peppas and Higuchi models.

Original languageEnglish
Pages (from-to)258-270
Number of pages13
JournalIndian Chemical Engineer
Volume55
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Dextran Sulfate
Dextran
Chitosan
Encapsulation
Capsules
Silicon Dioxide
Silica
Scanning electron microscopy
Dynamic light scattering
Surface morphology
Multilayers
Dissolution
Phosphates
Kinetics
moxifloxacin
Sulfates
Water
Pharmaceutical Preparations

Keywords

  • Biodegradable capsules
  • Dextran sulphate
  • Drug release
  • Encapsulation
  • Moxifloxacin hydrochloride

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Encapsulation and Release of Moxifloxacin Hydrochloride in Chitosan-Dextran Sulphate Microcapsules. / Devi, M. Geetha; Dutta, Susmita; Al Hinai, Ashraf Talib; Feroz, S.

In: Indian Chemical Engineer, Vol. 55, No. 4, 2013, p. 258-270.

Research output: Contribution to journalArticle

Devi, M. Geetha ; Dutta, Susmita ; Al Hinai, Ashraf Talib ; Feroz, S. / Encapsulation and Release of Moxifloxacin Hydrochloride in Chitosan-Dextran Sulphate Microcapsules. In: Indian Chemical Engineer. 2013 ; Vol. 55, No. 4. pp. 258-270.
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