Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex: Measurement, kinetic and thermodynamic studies

Emad A. Khudaish; Mohammed Al-Hinaai; Salim Al-Harthy; Karthik Laxman

doi:10.1016/j.electacta.2014.05.029

Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex: Measurement, kinetic and thermodynamic studies

Emad A. Khudaish^*, Mohammed Al-Hinaai, Salim Al-Harthy, Karthik Laxman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) ₃]^3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10^-5 cm² s^-1 and 3.21 × 10 ^-3 cm s^-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.

Original language	English
Pages (from-to)	319-326
Number of pages	8
Journal	Electrochimica Acta
Volume	135
DOIs	https://doi.org/10.1016/j.electacta.2014.05.029
Publication status	Published - Jul 20 2014
Externally published	Yes

Keywords

Chlorpheniramine maleate
Polytyramine
Sensors
Tris(bipyridyl)ruthenium (II)

ASJC Scopus subject areas

Chemical Engineering(all)
Electrochemistry

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10.1016/j.electacta.2014.05.029

Cite this

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title = "Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex: Measurement, kinetic and thermodynamic studies",

abstract = "A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.",

keywords = "Chlorpheniramine maleate, Polytyramine, Sensors, Tris(bipyridyl)ruthenium (II)",

author = "Khudaish, {Emad A.} and Mohammed Al-Hinaai and Salim Al-Harthy and Karthik Laxman",

note = "Funding Information: The authors would like to thank The Research Council (TRC) and Sultan Qaboos University (SQU), Sultanate of Oman, for supporting this work by the research grant numbers (RC/SCI/CHEM/11/01) and (IG/SCI/CHEM/02/05), respectively. ",

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doi = "10.1016/j.electacta.2014.05.029",

language = "English",

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journal = "Electrochimica Acta",

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TY - JOUR

T1 - Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex

T2 - Measurement, kinetic and thermodynamic studies

AU - Khudaish, Emad A.

AU - Al-Hinaai, Mohammed

AU - Al-Harthy, Salim

AU - Laxman, Karthik

N1 - Funding Information: The authors would like to thank The Research Council (TRC) and Sultan Qaboos University (SQU), Sultanate of Oman, for supporting this work by the research grant numbers (RC/SCI/CHEM/11/01) and (IG/SCI/CHEM/02/05), respectively.

PY - 2014/7/20

Y1 - 2014/7/20

N2 - A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.

AB - A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.

KW - Chlorpheniramine maleate

KW - Polytyramine

KW - Sensors

KW - Tris(bipyridyl)ruthenium (II)

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JO - Electrochimica Acta

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SN - 0013-4686

ER -

Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex: Measurement, kinetic and thermodynamic studies

Abstract

Keywords

ASJC Scopus subject areas

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