Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex

Measurement, kinetic and thermodynamic studies

Emad A. Khudaish, Mohammed Al-Hinaai, Salim Al-Harthy, Karthik Laxman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalElectrochimica Acta
Volume135
DOIs
Publication statusPublished - Jul 20 2014

Fingerprint

Chlorpheniramine
Ruthenium
Electrochemical oxidation
Thermodynamics
Solid-state sensors
Oxidation
2,2'-Dipyridyl
Kinetics
Glassy carbon
Voltammetry
Electrochemical impedance spectroscopy
Kinetic parameters
Rate constants
Hydrodynamics
X ray photoelectron spectroscopy
Electrodes
Electrons
Sensors
tris(2,2'-bipyridine)ruthenium II
Oxidation-Reduction

Keywords

  • Chlorpheniramine maleate
  • Polytyramine
  • Sensors
  • Tris(bipyridyl)ruthenium (II)

ASJC Scopus subject areas

  • Electrochemistry
  • Chemical Engineering(all)

Cite this

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title = "Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex: Measurement, kinetic and thermodynamic studies",
abstract = "A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.",
keywords = "Chlorpheniramine maleate, Polytyramine, Sensors, Tris(bipyridyl)ruthenium (II)",
author = "Khudaish, {Emad A.} and Mohammed Al-Hinaai and Salim Al-Harthy and Karthik Laxman",
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T1 - Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex

T2 - Measurement, kinetic and thermodynamic studies

AU - Khudaish, Emad A.

AU - Al-Hinaai, Mohammed

AU - Al-Harthy, Salim

AU - Laxman, Karthik

PY - 2014/7/20

Y1 - 2014/7/20

N2 - A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.

AB - A solid-state sensor based on polytyramine film deposited at glassy carbon electrode doped with tris(2,2′-bipyridyl)Ru(II) complex (Ru/Pty/GCE) was constructed electrochemically. A redox property represented by [Ru(bpy) 3]3+/2+ couple immobilized at the Pty moiety was characterized using typical voltammetric techniques. The XPS data and AFM images confirm the grafting of Ru species on the top of Pty while the electrochemical impedance spectroscopy (EIS) data supports the immobilization of both surface modifiers onto the GCE. The constructed sensor exhibits a substantial reactivity, stability and high sensitivity to chlorpheniramine maleate (CPM) oxidation. The detection limit (S/N = 3) was brought down to 338 nM using differential pulse voltammetry method. Thermodynamic and kinetic parameters were evaluated using hydrodynamic method. The apparent diffusion coefficient and the heterogeneous electron transfer rate constant for the CPM oxidation were 2.67 × 10-5 cm2 s-1 and 3.21 × 10 -3 cm s-1, respectively. Interference studies and real sample analysis were conducted with excellent performance and satisfactory results.

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KW - Sensors

KW - Tris(bipyridyl)ruthenium (II)

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