Effects of S-allyl cysteine on N-nitrosodiethylamine induced hepatocarcinogenesis: Variations in temporal patterns of circulatory tumor marker enzymes

Thamilarasan Manivasagam, Perumal Subramanian, Musthafa Mohamed Essa, Ganapathy Suthakar, Selvaraju Subash, Ramar Sivaperumal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, the protective effects of S-allyl cysteine on the temporal patterns of tumor marker enzymes in N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis were studied. Experimental animals (160-180 g) were divided into control, NDEA (single i.p. injection of 200 mg kg-1 body weight followed by weekly subcutaneous injections of 3 mL k-1 body weight CCl4) treated, NDEA+SAC (200 mg kg-1 body weight) treated and SAC treated groups. The characteristics of circadian rhythms (acrophase, amplitude and mesor) of tumor marker enzymes such as alkaline phosphatase (ALP), aspartate and alanine transaminases (ALT and AST) and γ-Glutamyl transpeptidase (GGT) were analysed. Variations in acrophase, mesor, amplitude and r and p-values were noted. The detectable circadian rhythms of tumor marker enzymes and their alterations during NDEA/SAC treatments, in the present study, deserve further investigation for the diagnosis, prognosis and for the therapeutic efficacy of cancer. As to conclude, this study indicates the necessity of more research to reveal the temporal interplay between the central biological clock (suprachaismatic nucleus), peripheral tissue (liver) based oscillators and cancer processes.

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalInternational Journal of Pharmacology
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 2006

Fingerprint

Diethylnitrosamine
Tumor Biomarkers
Body Weight
Enzymes
Circadian Rhythm
Biological Clocks
gamma-Glutamyltransferase
Subcutaneous Injections
Aspartate Aminotransferases
Alanine Transaminase
Alkaline Phosphatase
Neoplasms
Injections
S-allylcysteine
Liver
Therapeutics
Research

Keywords

  • Circadian
  • Experimental hepatocarcinogenesis
  • S-allyl cysteine
  • Tumor marker enzymes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of S-allyl cysteine on N-nitrosodiethylamine induced hepatocarcinogenesis : Variations in temporal patterns of circulatory tumor marker enzymes. / Manivasagam, Thamilarasan; Subramanian, Perumal; Essa, Musthafa Mohamed; Suthakar, Ganapathy; Subash, Selvaraju; Sivaperumal, Ramar.

In: International Journal of Pharmacology, Vol. 2, No. 1, 01.2006, p. 136-141.

Research output: Contribution to journalArticle

Manivasagam, Thamilarasan ; Subramanian, Perumal ; Essa, Musthafa Mohamed ; Suthakar, Ganapathy ; Subash, Selvaraju ; Sivaperumal, Ramar. / Effects of S-allyl cysteine on N-nitrosodiethylamine induced hepatocarcinogenesis : Variations in temporal patterns of circulatory tumor marker enzymes. In: International Journal of Pharmacology. 2006 ; Vol. 2, No. 1. pp. 136-141.
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