Effects of Pongamia pinnata on lipid peroxidation products and antioxidants in hyperammonemic rats: With reference to circadian variations

Mohamed Musthafa Mohamed Essa, Perumal Subramanian

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Effects of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-(AC)-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata (PPEt), and PPEt-treated. The characteristics of 24 h rhythms (acrophase, amplitude and mesor) of lipid peroxidation products (thiobarbituric acid reactive substances-TBARS) and antioxidants (reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT)) were analyzed. Elevated lipid peroxidation (increased mesor of TBARS) associated with decreased activities of antioxidants (decreased mesor of GPx, GSH, SOD and CAT) were found in hyperammonemic rats. Differences were also found in amplitude and 'r' values between the hyperammonemic rats and other experimental groups. These alterations clearly indicate that temporal redox status could be modulated by PPEt during hyperammonemic conditions, which may also play a crucial role in disease development.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalIranian Journal of Pharmacology and Therapeutics
Issue number2
Publication statusPublished - 2007



  • Antioxidants
  • Circadian
  • Hyperammonemia
  • Lipid peroxidation
  • Pongamia pinnata

ASJC Scopus subject areas

  • Pharmacology

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