TY - JOUR
T1 - Effects of Pongamia pinnata on lipid peroxidation products and antioxidants in hyperammonemic rats
T2 - With reference to circadian variations
AU - Essa, Mohamed Musthafa Mohamed
AU - Subramanian, Perumal
N1 - Funding Information:
ACKNOWLEDGMENTS We thank Christopher Anastasiou and other members of the Southwest Florida Water Management District for help in collecting samples and monitoring chlorophyll a and water transparency. Funding for the study was provided by the Southwest Florida Water Management District, Brooksville, Florida.
PY - 2007
Y1 - 2007
N2 - Effects of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-(AC)-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata (PPEt), and PPEt-treated. The characteristics of 24 h rhythms (acrophase, amplitude and mesor) of lipid peroxidation products (thiobarbituric acid reactive substances-TBARS) and antioxidants (reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT)) were analyzed. Elevated lipid peroxidation (increased mesor of TBARS) associated with decreased activities of antioxidants (decreased mesor of GPx, GSH, SOD and CAT) were found in hyperammonemic rats. Differences were also found in amplitude and 'r' values between the hyperammonemic rats and other experimental groups. These alterations clearly indicate that temporal redox status could be modulated by PPEt during hyperammonemic conditions, which may also play a crucial role in disease development.
AB - Effects of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-(AC)-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata (PPEt), and PPEt-treated. The characteristics of 24 h rhythms (acrophase, amplitude and mesor) of lipid peroxidation products (thiobarbituric acid reactive substances-TBARS) and antioxidants (reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT)) were analyzed. Elevated lipid peroxidation (increased mesor of TBARS) associated with decreased activities of antioxidants (decreased mesor of GPx, GSH, SOD and CAT) were found in hyperammonemic rats. Differences were also found in amplitude and 'r' values between the hyperammonemic rats and other experimental groups. These alterations clearly indicate that temporal redox status could be modulated by PPEt during hyperammonemic conditions, which may also play a crucial role in disease development.
KW - Antioxidants
KW - Circadian
KW - Hyperammonemia
KW - Lipid peroxidation
KW - Pongamia pinnata
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M3 - Article
AN - SCOPUS:55949121698
SN - 1735-2657
VL - 6
SP - 119
EP - 123
JO - Iranian Journal of Pharmacology and Therapeutics
JF - Iranian Journal of Pharmacology and Therapeutics
IS - 2
ER -