Effects of neuropeptide Y on mean circulatory filling pressure in intact and ganglionic-blocked conscious rats

Aly Abdelrahman, Catherine C Y Pang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The dose-response effects of neuropeptide Y (NPY) and the vehicle, 0.9% NaCl, on mean arterial pressure (MAP), heart rate (HR) and mean circulatory filling pressure (MCFP), an index of body venous tone, were examined in conscious, intact and hexamethonium-treated rats. Saline infusions in intact and hexamethonium-treated rats did not significantly affect MAP, HR and MCFP. The i.v. infusion of NPY in intact rats dose dependently increased MAP, decreased HR, but did not alter MCFP. In the presence of hexamethonium, the pressor effect of NPY was enhanced, the lack of MCFP effect remained and the bradycardic effect was markedly attenuated. Our results suggest that NPY has moderate effects on MAP, but negligible effects on body venous tone.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalEuropean Journal of Pharmacology
Volume205
Issue number3
DOIs
Publication statusPublished - Dec 3 1991

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Neuropeptide Y
Hexamethonium
Arterial Pressure
Pressure
Heart Rate

Keywords

  • Circulatory filling pressure (mean)
  • Ganglion blockers
  • Neuropeptide (NPY)
  • Venous tone

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of neuropeptide Y on mean circulatory filling pressure in intact and ganglionic-blocked conscious rats. / Abdelrahman, Aly; Pang, Catherine C Y.

In: European Journal of Pharmacology, Vol. 205, No. 3, 03.12.1991, p. 253-257.

Research output: Contribution to journalArticle

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