Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus

Adel T. Abu-Heija, Majeda R. Al-Bash, Moza A. Al-Kalbani

Research output: Contribution to journalArticle

Abstract

Objectives: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. Methods: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24-28 weeks of gestation. When the venous plasma glucose concentration (VPG) reached >7.8 mmol/l after 1 h, the OGCT was considered to be positive. Women with positive OGCTs had a confirmatory diagnosis of GDM, which was established by performing a 2-h 75 g oral glucose tolerance test (OGTT). When either fasting or post-2-h 75 g OGTT values were >5.5 mmol/l or >8 mmol/l, respectively, women were considered diabetic. Results: This study screened 307 women and identified 83 (27.03%) OGCT-positive and 23 (7.5%) GDM-positive cases. The incidences of a positive OGCT and GDM increased significantly with increasing maternal age from 20.0% to 2.2%, respectively, in women aged ≤25 years to 37.8% and 14.7%, respectively, in women aged >35 years (p = 0.02 and p = 0.009, respectively). The incidences of a positive OGCT and GDM increased markedly with increasing pre-pregnancy BMI, from 19.8% to 3.8%, respectively, in women with BMIs ≤25 kg/m2 to 37.8% and 9.9%, respectively, in women with BMIs >25 kg/m2 (p = 0.02 and p = 0.04, respectively). Conclusion: Maternal age and pre-pregnancy BMI have profound effects on the incidences of a positive OGCT and GDM.

Original languageEnglish
JournalJournal of Taibah University Medical Sciences
DOIs
Publication statusAccepted/In press - Nov 22 2016

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Gestational Diabetes
Maternal Age
Parity
Body Mass Index
Glucose
Pregnancy
Incidence
Glucose Tolerance Test
Pregnant Women
Fasting

Keywords

  • Age
  • Body mass index
  • Gestational diabetes
  • Glucose challenge test
  • Parity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{dfb02eba6eea4fae9c526c0110f840b5,
title = "Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus",
abstract = "Objectives: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. Methods: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24-28 weeks of gestation. When the venous plasma glucose concentration (VPG) reached >7.8 mmol/l after 1 h, the OGCT was considered to be positive. Women with positive OGCTs had a confirmatory diagnosis of GDM, which was established by performing a 2-h 75 g oral glucose tolerance test (OGTT). When either fasting or post-2-h 75 g OGTT values were >5.5 mmol/l or >8 mmol/l, respectively, women were considered diabetic. Results: This study screened 307 women and identified 83 (27.03{\%}) OGCT-positive and 23 (7.5{\%}) GDM-positive cases. The incidences of a positive OGCT and GDM increased significantly with increasing maternal age from 20.0{\%} to 2.2{\%}, respectively, in women aged ≤25 years to 37.8{\%} and 14.7{\%}, respectively, in women aged >35 years (p = 0.02 and p = 0.009, respectively). The incidences of a positive OGCT and GDM increased markedly with increasing pre-pregnancy BMI, from 19.8{\%} to 3.8{\%}, respectively, in women with BMIs ≤25 kg/m2 to 37.8{\%} and 9.9{\%}, respectively, in women with BMIs >25 kg/m2 (p = 0.02 and p = 0.04, respectively). Conclusion: Maternal age and pre-pregnancy BMI have profound effects on the incidences of a positive OGCT and GDM.",
keywords = "Age, Body mass index, Gestational diabetes, Glucose challenge test, Parity",
author = "Abu-Heija, {Adel T.} and Al-Bash, {Majeda R.} and Al-Kalbani, {Moza A.}",
year = "2016",
month = "11",
day = "22",
doi = "10.1016/j.jtumed.2017.01.005",
language = "English",
journal = "Journal of Taibah University Medical Sciences",
issn = "1658-3612",
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TY - JOUR

T1 - Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus

AU - Abu-Heija, Adel T.

AU - Al-Bash, Majeda R.

AU - Al-Kalbani, Moza A.

PY - 2016/11/22

Y1 - 2016/11/22

N2 - Objectives: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. Methods: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24-28 weeks of gestation. When the venous plasma glucose concentration (VPG) reached >7.8 mmol/l after 1 h, the OGCT was considered to be positive. Women with positive OGCTs had a confirmatory diagnosis of GDM, which was established by performing a 2-h 75 g oral glucose tolerance test (OGTT). When either fasting or post-2-h 75 g OGTT values were >5.5 mmol/l or >8 mmol/l, respectively, women were considered diabetic. Results: This study screened 307 women and identified 83 (27.03%) OGCT-positive and 23 (7.5%) GDM-positive cases. The incidences of a positive OGCT and GDM increased significantly with increasing maternal age from 20.0% to 2.2%, respectively, in women aged ≤25 years to 37.8% and 14.7%, respectively, in women aged >35 years (p = 0.02 and p = 0.009, respectively). The incidences of a positive OGCT and GDM increased markedly with increasing pre-pregnancy BMI, from 19.8% to 3.8%, respectively, in women with BMIs ≤25 kg/m2 to 37.8% and 9.9%, respectively, in women with BMIs >25 kg/m2 (p = 0.02 and p = 0.04, respectively). Conclusion: Maternal age and pre-pregnancy BMI have profound effects on the incidences of a positive OGCT and GDM.

AB - Objectives: To study the effects of age, parity and body mass index (BMI) on the incidence of a positive 50 g glucose challenge test (OGCT) and gestational diabetes mellitus (GDM) in healthy pregnant Omani women. Methods: A 50 g OGCT was performed on 307 healthy pregnant Omani women at 24-28 weeks of gestation. When the venous plasma glucose concentration (VPG) reached >7.8 mmol/l after 1 h, the OGCT was considered to be positive. Women with positive OGCTs had a confirmatory diagnosis of GDM, which was established by performing a 2-h 75 g oral glucose tolerance test (OGTT). When either fasting or post-2-h 75 g OGTT values were >5.5 mmol/l or >8 mmol/l, respectively, women were considered diabetic. Results: This study screened 307 women and identified 83 (27.03%) OGCT-positive and 23 (7.5%) GDM-positive cases. The incidences of a positive OGCT and GDM increased significantly with increasing maternal age from 20.0% to 2.2%, respectively, in women aged ≤25 years to 37.8% and 14.7%, respectively, in women aged >35 years (p = 0.02 and p = 0.009, respectively). The incidences of a positive OGCT and GDM increased markedly with increasing pre-pregnancy BMI, from 19.8% to 3.8%, respectively, in women with BMIs ≤25 kg/m2 to 37.8% and 9.9%, respectively, in women with BMIs >25 kg/m2 (p = 0.02 and p = 0.04, respectively). Conclusion: Maternal age and pre-pregnancy BMI have profound effects on the incidences of a positive OGCT and GDM.

KW - Age

KW - Body mass index

KW - Gestational diabetes

KW - Glucose challenge test

KW - Parity

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U2 - 10.1016/j.jtumed.2017.01.005

DO - 10.1016/j.jtumed.2017.01.005

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JO - Journal of Taibah University Medical Sciences

JF - Journal of Taibah University Medical Sciences

SN - 1658-3612

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