Effects of low dose of aliskiren on isoproterenol-induced acute myocardial infarction in rats

I. Bin-Jaliah, A. M. Hussein, Hussein Sakr, E. A. Eid

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study examined the effects of aliskiren (Ali) (direct renin inhibitor) on serum cardiac enzymes (LDH and CK-MB), electrocardiography (ECG) changes, myocardial oxidative stress markers (MDA, CAT, and GSH) and the expression of Bcl2, HO-1, and Nrf2 genes in isoproterenol (ISO)-induced myocardial infarction (MI). A total of 40 male albino rats were allocated into four groups, (1) normal control (NC) group, (2) Ali group (rats received Ali at 10 mg/kg/day p.o. for 5 days), (3) ISO group (rats received ISO 150 mg/kg i.p. for two consecutive days at 24 h intervals), and (4) Ali + ISO group (rats received ISO + Ali at 10 mg/kg/day p.o. for 5 days from the 2nd dose of ISO). ISO group showed significant rise in serum cardiac enzymes (CK-MB and LDH), myocardial damage scores, myocardial MDA, HO-1, myocardial Nrf2 expression with significant reduction in myocardial antioxidants (CAT and GSH), and Bcl2 expression compared to the normal group (p < 0.05). ECG showed ST segment elevation, prolonged QT interval and QRS complex, and increased heart rate in ISO group. Co-administration of Ali and ISO caused significant increase in cardiac enzymes and morphology with increase in MDA, serum K, and creatinine with significant decrease in Bcl2, HO-1, and Nrf2 without significant changes in ECG parameters compared to ISO group. We concluded that low dose of Ali seems to exacerbate the myocardial injury in ISO-MI, which might be due to the enhanced oxidative stress and apoptosis.

Original languageEnglish
Pages (from-to)127-144
Number of pages18
JournalPhysiology International
Volume105
Issue number2
DOIs
Publication statusPublished - Jun 1 2018

Keywords

  • Aliskiren
  • Bcl2
  • HO-1
  • Isoproterenol
  • Myocardial infarction
  • Nrf2
  • Rats

ASJC Scopus subject areas

  • Physiology (medical)

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