Effects of Gum Arabic in rats with adenine-induced chronic renal failure

Badreldin H. Ali, Suhail Al-Salam, Isehaq Al Husseni, Rana R. Kayed, Noura Al-Masroori, Thuriya Al-Harthi, Mohamed Al Zaabi, Abderrahim Nemmar

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Gum Arabic (GA [Acacia senegal]) is reputed, in Arabian medicinal practices, to be useful in treating patients with chronic renal failure (CRF), albeit without strong scientific evidence. We have previously shown that GA had no significant effect in rats with CRF induced by surgical nephrectomy. Here, we used another animal model of human CRF (feeding adenine at a concentration of 0.75%w/w for four weeks) to test the effect of GA on CRF. Renal morphology and measurements of plasma concentrations of urea and creatinine (Cr), and Cr clearance, in addition to urinary volume, osmolarity and protein concentrations, and N-acetylglucosamine and lactate dehydrogenase activities were performed. Interleukin-6 and the total antioxidant levels in urine, as well as the activity of superoxide dismutase in renal tissues, were estimated. Adenine feeding resulted in marked renal damage. GA (6%w/v and 12%w/v in drinking water for four consecutive weeks) significantly ameliorated the adverse biochemical alterations indicative of renal failure, abated the decrease in body weight and reduced the glomerular, tubular and interstitial lesions induced by adenine. Our study provides evidence that GA attenuated renal dysfunction in this model of CRF, suggesting a promising potential for it in protecting against renal failure progression. The mechanism(s) of this nephroprotection is uncertain but may involve anti-oxidant and/or anti-inflammatory actions.

Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalExperimental Biology and Medicine
Volume235
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Gum Arabic
Adenine
Chronic Kidney Failure
Rats
Creatinine
Kidney
Acetylglucosamine
Renal Insufficiency
L-Lactate Dehydrogenase
Oxidants
Drinking Water
Superoxide Dismutase
Urea
Interleukin-6
Animals
Anti-Inflammatory Agents
Acacia
Antioxidants
Senegal
Tissue

Keywords

  • Adenine
  • Chronic renal failure
  • Gum Arabic
  • Rats

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ali, B. H., Al-Salam, S., Al Husseni, I., Kayed, R. R., Al-Masroori, N., Al-Harthi, T., ... Nemmar, A. (2010). Effects of Gum Arabic in rats with adenine-induced chronic renal failure. Experimental Biology and Medicine, 235(3), 373-382. https://doi.org/10.1258/ebm.2009.009214

Effects of Gum Arabic in rats with adenine-induced chronic renal failure. / Ali, Badreldin H.; Al-Salam, Suhail; Al Husseni, Isehaq; Kayed, Rana R.; Al-Masroori, Noura; Al-Harthi, Thuriya; Al Zaabi, Mohamed; Nemmar, Abderrahim.

In: Experimental Biology and Medicine, Vol. 235, No. 3, 03.2010, p. 373-382.

Research output: Contribution to journalArticle

Ali, BH, Al-Salam, S, Al Husseni, I, Kayed, RR, Al-Masroori, N, Al-Harthi, T, Al Zaabi, M & Nemmar, A 2010, 'Effects of Gum Arabic in rats with adenine-induced chronic renal failure', Experimental Biology and Medicine, vol. 235, no. 3, pp. 373-382. https://doi.org/10.1258/ebm.2009.009214
Ali BH, Al-Salam S, Al Husseni I, Kayed RR, Al-Masroori N, Al-Harthi T et al. Effects of Gum Arabic in rats with adenine-induced chronic renal failure. Experimental Biology and Medicine. 2010 Mar;235(3):373-382. https://doi.org/10.1258/ebm.2009.009214
Ali, Badreldin H. ; Al-Salam, Suhail ; Al Husseni, Isehaq ; Kayed, Rana R. ; Al-Masroori, Noura ; Al-Harthi, Thuriya ; Al Zaabi, Mohamed ; Nemmar, Abderrahim. / Effects of Gum Arabic in rats with adenine-induced chronic renal failure. In: Experimental Biology and Medicine. 2010 ; Vol. 235, No. 3. pp. 373-382.
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