Effects of Gum Arabic in rats with adenine-induced chronic renal failure

Badreldin H. Ali, Suhail Al-Salam, Isehaq Al Husseni, Rana R. Kayed, Noura Al-Masroori, Thuriya Al-Harthi, Mohamed Al Zaabi, Abderrahim Nemmar

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Abstract

Gum Arabic (GA [Acacia senegal]) is reputed, in Arabian medicinal practices, to be useful in treating patients with chronic renal failure (CRF), albeit without strong scientific evidence. We have previously shown that GA had no significant effect in rats with CRF induced by surgical nephrectomy. Here, we used another animal model of human CRF (feeding adenine at a concentration of 0.75%w/w for four weeks) to test the effect of GA on CRF. Renal morphology and measurements of plasma concentrations of urea and creatinine (Cr), and Cr clearance, in addition to urinary volume, osmolarity and protein concentrations, and N-acetylglucosamine and lactate dehydrogenase activities were performed. Interleukin-6 and the total antioxidant levels in urine, as well as the activity of superoxide dismutase in renal tissues, were estimated. Adenine feeding resulted in marked renal damage. GA (6%w/v and 12%w/v in drinking water for four consecutive weeks) significantly ameliorated the adverse biochemical alterations indicative of renal failure, abated the decrease in body weight and reduced the glomerular, tubular and interstitial lesions induced by adenine. Our study provides evidence that GA attenuated renal dysfunction in this model of CRF, suggesting a promising potential for it in protecting against renal failure progression. The mechanism(s) of this nephroprotection is uncertain but may involve anti-oxidant and/or anti-inflammatory actions.

Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalExperimental Biology and Medicine
Volume235
Issue number3
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Adenine
  • Chronic renal failure
  • Gum Arabic
  • Rats

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ali, B. H., Al-Salam, S., Al Husseni, I., Kayed, R. R., Al-Masroori, N., Al-Harthi, T., Al Zaabi, M., & Nemmar, A. (2010). Effects of Gum Arabic in rats with adenine-induced chronic renal failure. Experimental Biology and Medicine, 235(3), 373-382. https://doi.org/10.1258/ebm.2009.009214