Effects of fried potato chip supplementation on mouse pregnancy and fetal development

Hassan I. El-Sayyad, Mohamed H. Abou-Egla, Fawkia I. El-Sayyad, Heba A. El-Ghawet, Rajiv L. Gaur, Augusta Fernando, Madhwa H G Raj, Allal Ouhtit

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: Acrylamide (ACR), a proven rodent carcinogen, is present at significantly high quantities in commonly consumed foods such as potato chips, raising a health concern worldwide. Methods: The effects of ACR and fried potato chips (FPC) on pregnant mice and their offspring before and after birth were investigated and compared. Results: In the pregnant mice, similar histologic abnormalities were found in various tissues for ACR intoxication and FPC supplementation. Drastic alterations were mainly seen in the liver, kidney, heart muscle, and epiphyseal cartilage of experimental dams. ACR and FPC increased the rate of abortion and neonatal mortality and decreased the total number, body weight, size, and crown-rump length of the offspring before and after birth. Interestingly, however, higher rates of congenital malformations were observed in the FPC-treated group. Although ossification of axial and appendicular bones was markedly retarded during fetal development, some ossified bones were missing in newly born offspring of treated groups. Furthermore, the incidence of missing ossification centers was higher in the FPC-treated than in the ACR-treated neonates. Conclusion: These results suggest that FPC can cause hazardous health effects and warrant a systematic study on the health effects of consumption of FPC and French fries in the general population.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalNutrition
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Solanum tuberosum
Fetal Development
Acrylamide
Pregnancy
Osteogenesis
Parturition
Crown-Rump Length
Bone and Bones
Growth Plate
Induced Abortion
Health
Infant Mortality
Body Size
Carcinogens
Rodentia
Myocardium
Body Weight
Kidney
Food
Liver

Keywords

  • Acrylamide
  • Fetal development
  • Fried potato chips
  • Pregnant mice

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

El-Sayyad, H. I., Abou-Egla, M. H., El-Sayyad, F. I., El-Ghawet, H. A., Gaur, R. L., Fernando, A., ... Ouhtit, A. (2011). Effects of fried potato chip supplementation on mouse pregnancy and fetal development. Nutrition, 27(3), 343-350. https://doi.org/10.1016/j.nut.2010.11.005

Effects of fried potato chip supplementation on mouse pregnancy and fetal development. / El-Sayyad, Hassan I.; Abou-Egla, Mohamed H.; El-Sayyad, Fawkia I.; El-Ghawet, Heba A.; Gaur, Rajiv L.; Fernando, Augusta; Raj, Madhwa H G; Ouhtit, Allal.

In: Nutrition, Vol. 27, No. 3, 03.2011, p. 343-350.

Research output: Contribution to journalArticle

El-Sayyad, HI, Abou-Egla, MH, El-Sayyad, FI, El-Ghawet, HA, Gaur, RL, Fernando, A, Raj, MHG & Ouhtit, A 2011, 'Effects of fried potato chip supplementation on mouse pregnancy and fetal development', Nutrition, vol. 27, no. 3, pp. 343-350. https://doi.org/10.1016/j.nut.2010.11.005
El-Sayyad HI, Abou-Egla MH, El-Sayyad FI, El-Ghawet HA, Gaur RL, Fernando A et al. Effects of fried potato chip supplementation on mouse pregnancy and fetal development. Nutrition. 2011 Mar;27(3):343-350. https://doi.org/10.1016/j.nut.2010.11.005
El-Sayyad, Hassan I. ; Abou-Egla, Mohamed H. ; El-Sayyad, Fawkia I. ; El-Ghawet, Heba A. ; Gaur, Rajiv L. ; Fernando, Augusta ; Raj, Madhwa H G ; Ouhtit, Allal. / Effects of fried potato chip supplementation on mouse pregnancy and fetal development. In: Nutrition. 2011 ; Vol. 27, No. 3. pp. 343-350.
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