Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men

Jason M R Gill, Ali Al-Mamari, William R. Ferrell, Stephen J. Cleland, Naveed Sattar, Chris J. Packard, John R. Petrie, Muriel J. Caslake

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Prior moderate exercise reduces postprandial triglyceride concentrations. Its effects on the concentrations, compositions and potential atherogenicity of lipoprotein subfractions were investigated in the present study. Twenty normoglycaemic middle-aged men each underwent two fat tolerance tests (blood taken fasting and for 8 h after a meal containing 80 g fat and 70 g carbohydrate). On the afternoon before one test, subjects performed a 90-min treadmill walk (exercise); no exercise was performed before the control test. Prior exercise significantly reduced postprandial concentrations of chylomicrons (Sf >400) by 28.6% (absolute reduction 14.6 mg dl-1), of large VLDL1 (Sf 60-400) by 34.4% (39.7 mg dl-1) and of small VLDL2 (Sf 20-60) by 23.0% (9.6 mg dl-1). Over 95% of VLDL1 and VLDL2 comprised apolipoprotein (apo) B100-containing particles. Exercise also reduced postprandial remnant-like lipoprotein cholesterol (by 35%) and triglyceride concentrations (by 29%). Postprandial apo CIII/apo B and apo E/apo B ratios in VLDL1 were lower following exercise. Postprandial cholesteryl ester/triglyceride ratios were lower in VLDL1 and VLDL2 and higher in HDL 2 following exercise. These data suggest that the effect of prior moderate exercise on VLDL1 is quantitatively greater than its effect on chylomicrons and that, in addition to reducing lipoprotein concentrations, exercise induces compositional changes to lipoprotein species which are likely to influence their metabolism and atherogenicity.

Original languageEnglish
Pages (from-to)87-96
Number of pages10
JournalAtherosclerosis
Volume185
Issue number1
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Apolipoproteins
Lipoproteins
Exercise
Chylomicrons
Apolipoproteins B
Triglycerides
Fats
Apolipoprotein C-III
HDL2 Lipoprotein
Cholesterol Esters
Hematologic Tests
Apolipoproteins E
Meals
Fasting
Carbohydrates

Keywords

  • Apolipoprotein
  • Cholesteryl ester
  • Exercise
  • Postprandial
  • Remnant-like lipoprotein
  • Triglyceride
  • VLDL

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men. / Gill, Jason M R; Al-Mamari, Ali; Ferrell, William R.; Cleland, Stephen J.; Sattar, Naveed; Packard, Chris J.; Petrie, John R.; Caslake, Muriel J.

In: Atherosclerosis, Vol. 185, No. 1, 03.2006, p. 87-96.

Research output: Contribution to journalArticle

Gill, Jason M R ; Al-Mamari, Ali ; Ferrell, William R. ; Cleland, Stephen J. ; Sattar, Naveed ; Packard, Chris J. ; Petrie, John R. ; Caslake, Muriel J. / Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men. In: Atherosclerosis. 2006 ; Vol. 185, No. 1. pp. 87-96.
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