Effects of α-ketoglutarate on lipid peroxidation and antioxidant status during chronic ethanol administration in wistar rats

Selvaraj Velvizhi, Thiyagarajan Nagalashmi, Mustafa Mohamed Essa, Kadiyala Babu Dakshayani, Perumal Subramanian

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects of α-ketoglutarate (α-KG) on ethanol-induced hepatotoxicity were studied in biochemical experiments in rats. The levels of serum transaminases and thiobarbituric acid reactive substances were significantly increased in ethanol-treated rats. These levels were significantly decreased in α-KG- and ethanol-treated rats. Further, non-enzymatic (vitamins C and E) and enzymatic (superoxide dismutase and catalase) antioxidants were significantly decreased in ethanol-treated rats, and were increased in α-KG-and ethanol-treated rats. The biochemical alterations during α-KG treatment could be due to (i) the participation of α-KG in the non-enzymatic oxidative decarboxylation in the hydrogen peroxide decomposition process and (ii) enhancing the proper metabolism of fats which could suppress oxygen radical generation and thus prevent the lipid peroxidative damages in rats.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalPolish Journal of Pharmacology
Volume54
Issue number3
Publication statusPublished - 2002

Fingerprint

Lipid Peroxidation
Wistar Rats
Ethanol
Antioxidants
Decarboxylation
Thiobarbituric Acid Reactive Substances
Transaminases
Vitamin E
Catalase
Hydrogen Peroxide
Ascorbic Acid
Superoxide Dismutase
Reactive Oxygen Species
Fats
Lipids
Serum

Keywords

  • α-ketoglutarate
  • Antioxidants
  • Ethanol
  • Lipid peroxidation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of α-ketoglutarate on lipid peroxidation and antioxidant status during chronic ethanol administration in wistar rats. / Velvizhi, Selvaraj; Nagalashmi, Thiyagarajan; Essa, Mustafa Mohamed; Dakshayani, Kadiyala Babu; Subramanian, Perumal.

In: Polish Journal of Pharmacology, Vol. 54, No. 3, 2002, p. 231-236.

Research output: Contribution to journalArticle

Velvizhi, Selvaraj ; Nagalashmi, Thiyagarajan ; Essa, Mustafa Mohamed ; Dakshayani, Kadiyala Babu ; Subramanian, Perumal. / Effects of α-ketoglutarate on lipid peroxidation and antioxidant status during chronic ethanol administration in wistar rats. In: Polish Journal of Pharmacology. 2002 ; Vol. 54, No. 3. pp. 231-236.
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