Effect of vasoactive drugs on tumour blood flow as determined by 2h nuclear magnetic resonance spectroscopy

Ikram A. Burney; Ross J. Maxwell; Stan B. Field; Cheryl L. McCoy; John R. Griffiths

doi:10.3109/02841869509093991

Effect of vasoactive drugs on tumour blood flow as determined by ²h nuclear magnetic resonance spectroscopy

Ikram A. Burney, Ross J. Maxwell^*, Stan B. Field, Cheryl L. McCoy, John R. Griffiths

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A selective reduction in tumour blood flow (TBF) could enhance the effects of hyperthermia treatment and of drugs toxic to hypoxic cells. Vasodilator-induced changes in TBF were monitored in transplanted rat fibrosarcomas by non-invasively measuring the uptake of D₂O using ²H nuclear magnetic resonance spectroscopy. Hydralazine (1 or 5 mg kg^-1) caused a large (45% reduction in mean arterial blood pressure (MABP) and a 40-60% reduction in TBF. Low-dose hydralazine (0.1 mg kg^-1) caused a 20% reduction in MABP but no significant change in TBF. The doses of prazosin (1 mg kg^-1) and calcitonin-gene related peptide (CGRP, 1 nmol kg^-1) which caused a 20% reduction in MABP led to a 50-60% reduction in TBF. These results demonstrate the advantage of prazosin and CGRP over hydralazine for the reduction of TBF despite a small hypotensive effect. CGRP may be the most suitable of these agents for clinical use because of its short physiological half-life.

Original language	English
Pages (from-to)	367-371
Number of pages	5
Journal	Acta Oncologica
Volume	34
Issue number	3
DOIs	https://doi.org/10.3109/02841869509093991
Publication status	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

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title = "Effect of vasoactive drugs on tumour blood flow as determined by 2h nuclear magnetic resonance spectroscopy",

abstract = "A selective reduction in tumour blood flow (TBF) could enhance the effects of hyperthermia treatment and of drugs toxic to hypoxic cells. Vasodilator-induced changes in TBF were monitored in transplanted rat fibrosarcomas by non-invasively measuring the uptake of D2O using 2H nuclear magnetic resonance spectroscopy. Hydralazine (1 or 5 mg kg-1) caused a large (45% reduction in mean arterial blood pressure (MABP) and a 40-60% reduction in TBF. Low-dose hydralazine (0.1 mg kg-1) caused a 20% reduction in MABP but no significant change in TBF. The doses of prazosin (1 mg kg-1) and calcitonin-gene related peptide (CGRP, 1 nmol kg-1) which caused a 20% reduction in MABP led to a 50-60% reduction in TBF. These results demonstrate the advantage of prazosin and CGRP over hydralazine for the reduction of TBF despite a small hypotensive effect. CGRP may be the most suitable of these agents for clinical use because of its short physiological half-life.",

author = "Burney, {Ikram A.} and Maxwell, {Ross J.} and Field, {Stan B.} and McCoy, {Cheryl L.} and Griffiths, {John R.}",

note = "Funding Information: This work was supported by the Cancer Research Campaign and the Medical Research Council, UK.",

year = "1995",

doi = "10.3109/02841869509093991",

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T1 - Effect of vasoactive drugs on tumour blood flow as determined by 2h nuclear magnetic resonance spectroscopy

AU - Burney, Ikram A.

AU - Maxwell, Ross J.

AU - Field, Stan B.

AU - McCoy, Cheryl L.

AU - Griffiths, John R.

N1 - Funding Information: This work was supported by the Cancer Research Campaign and the Medical Research Council, UK.

PY - 1995

Y1 - 1995

N2 - A selective reduction in tumour blood flow (TBF) could enhance the effects of hyperthermia treatment and of drugs toxic to hypoxic cells. Vasodilator-induced changes in TBF were monitored in transplanted rat fibrosarcomas by non-invasively measuring the uptake of D2O using 2H nuclear magnetic resonance spectroscopy. Hydralazine (1 or 5 mg kg-1) caused a large (45% reduction in mean arterial blood pressure (MABP) and a 40-60% reduction in TBF. Low-dose hydralazine (0.1 mg kg-1) caused a 20% reduction in MABP but no significant change in TBF. The doses of prazosin (1 mg kg-1) and calcitonin-gene related peptide (CGRP, 1 nmol kg-1) which caused a 20% reduction in MABP led to a 50-60% reduction in TBF. These results demonstrate the advantage of prazosin and CGRP over hydralazine for the reduction of TBF despite a small hypotensive effect. CGRP may be the most suitable of these agents for clinical use because of its short physiological half-life.

AB - A selective reduction in tumour blood flow (TBF) could enhance the effects of hyperthermia treatment and of drugs toxic to hypoxic cells. Vasodilator-induced changes in TBF were monitored in transplanted rat fibrosarcomas by non-invasively measuring the uptake of D2O using 2H nuclear magnetic resonance spectroscopy. Hydralazine (1 or 5 mg kg-1) caused a large (45% reduction in mean arterial blood pressure (MABP) and a 40-60% reduction in TBF. Low-dose hydralazine (0.1 mg kg-1) caused a 20% reduction in MABP but no significant change in TBF. The doses of prazosin (1 mg kg-1) and calcitonin-gene related peptide (CGRP, 1 nmol kg-1) which caused a 20% reduction in MABP led to a 50-60% reduction in TBF. These results demonstrate the advantage of prazosin and CGRP over hydralazine for the reduction of TBF despite a small hypotensive effect. CGRP may be the most suitable of these agents for clinical use because of its short physiological half-life.

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Effect of vasoactive drugs on tumour blood flow as determined by ²h nuclear magnetic resonance spectroscopy

Abstract

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