Effect of Teucrium stocksianum on paracetamol-induced hepatotoxicity in mice

R. A. Rasheed, B. H. Ali*, A. K. Bashir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

1. 1. Hepatoprotective activity of an ethanolic extract of Teucrium stocksianum was investigated against paracetamol-induced hepatic damage in mice. 2. 2. Paracetamol at an oral dose of 0.6 g/kg produced about 94% mortality in mice while pretreatment with the plant extract (0.5 and 1 g/kg for 5 days) reduced the death rate to 0%. 3. 3. Paracetamol (0.6 g/kg, orally) produced liver damage as manifested by significant rises in liver weight, plasma aspartate aminotransferase (AST) activity and bilirubin concentration, pentobarbitone-induced sleeping time, and by the significant depletion of reduced glutathione (GSH) in the liver. 4. 4. Pretreatment of mice with T. stocksianum at the above doses significantly ameliorated all the paracetamol-induced signs of liver damage described above. 5. 5. T. stocksianum did not produce any lethality or adverse effects in the livers of treated mice. 6. 6. These results indicate that T. stocksianum ethanolic extract contains hepatoprotective constituents, and suggest further work on the isolation and characterization of these constituents which may potentially be used as hepatoprotective agents.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalGeneral Pharmacology
Volume26
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • Hepatotoxicity
  • mice
  • paracetamol
  • Teucrium stocksianum

ASJC Scopus subject areas

  • Pharmacology

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