Effect of Rhazya stricta Decne on monoamine oxidase and cholinesterase activity and brain biogenic amine levels in rats

B. H. Ali, M. O M Tanira, A. K. Bashir, A. A. Al-Qarawi

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4 Citations (Scopus)

Abstract

The effect of treatment with the medicinal plant Rhazya stricta Decne, on monoamine oxidase (MAO) and cholinesterase activity, and on the concentration of brain biogenic amines was studied in rats. R. stricta extract, at doses of 0.2 and 0.5 g kg-1, significantly (P <0.05-0.01) increased the hepatic and cerebral activity of MAO by 36-127%. The higher doses used (2.0 and 8.0 g kg-1) produced smaller (10-26%) and statistically insignificant increases in MAO activity in liver and brain. Cholinesterase activity in blood, liver and brain was not significantly influenced by treatment with R. stricta. The concentrations of the measured biogenic amines (noradrenaline, adrenaline, 5-hydroxytryptamine and dopamine) were significantly lowered in rats treated with R. stricta. The observed increase in MAO activity may be responsible for the lowered biogenic amines levels and may, in part, be responsible for the pharmacological effects of R. stricta extract in rats.

Original languageEnglish
Pages (from-to)1297-1300
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume52
Issue number10
Publication statusPublished - 2000

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Apocynaceae
Biogenic Amines
Cholinesterases
Monoamine Oxidase
Brain
Liver
Medicinal Plants
Epinephrine
Dopamine
Serotonin
Norepinephrine
Pharmacology

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Effect of Rhazya stricta Decne on monoamine oxidase and cholinesterase activity and brain biogenic amine levels in rats. / Ali, B. H.; Tanira, M. O M; Bashir, A. K.; Al-Qarawi, A. A.

In: Journal of Pharmacy and Pharmacology, Vol. 52, No. 10, 2000, p. 1297-1300.

Research output: Contribution to journalArticle

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