This study proposed an investigation on the performance of the jet impingement microchannel heat sink infused with cylindrical passive structures called pillars at the centerline of the channel. Array of nozzles were designed on the top of the microchannel, and pillars were designed at the center of two neighboring nozzles. Numerical modelling and simulation of conjugate solid–fluid heat transfer is performed by using finite volume-based commercial Ansys CFX software. Analysis was done for the effect of nozzle inclination angle on the hydraulic and thermal characteristics of the hybrid MCHS. Characteristic parameters such as heat transfer coefficient, thermal resistance, wall temperature, and pressure drop were observed for Reynolds number varied from 100 to 400 and nozzle impingement angle varied in between 30° and 90°. Improvement in heat transfer occurred with increasing the Re as well as inclination angle. Highest heat transfer coefficient and lowest bottom wall temperature are obtained for the 60° nozzle angle. Moreover, with increasing the inclination angle, pressure drop is reducing, but with increasing the Re, pressure drop is increasing.