Effect of lead exposure on the erythrocytic antioxidant levels in goats

H. M. Mousa, A. A. Al-Qarawi, B. H. Ali, H. A A Rahman, S. A. Elmougy

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Fifteen adult female goats were orally exposed to 5.46 mg lead (as lead acetate) per kg body weight daily for 2 weeks to study the antioxidant enzymes of the erythrocyte, lipid peroxide level, total thiol groups and total antioxidant status (TAS) in plasma. Ten goats served as unexposed control. Blood samples were collected before exposure (day O) and on days 7 and 14. Ten per cent erythrocyte haemolysate was prepared and analysed for glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), total thiol groups and lipid peroxide. TAS was determined in plasma. There was a significant (P <0.05) increase of erythrocytic GPx, SOD, CAT, total thiol groups and TAS on day 7 which was followed by a significant (P <0.05) decrease of all these parameters on day 14. Lipid peroxide level increased significantly (P <0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity.

Original languageEnglish
Pages (from-to)531-534
Number of pages4
JournalJournal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine
Volume49
Issue number10
Publication statusPublished - 2002

Fingerprint

Goats
Lipid Peroxides
Antioxidants
peroxides
thiols
goats
Sulfhydryl Compounds
antioxidants
Glutathione Peroxidase
glutathione peroxidase
Catalase
Superoxide Dismutase
catalase
superoxide dismutase
erythrocytes
lipids
Erythrocytes
lead acetate
lead poisoning
Lead Poisoning

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Effect of lead exposure on the erythrocytic antioxidant levels in goats. / Mousa, H. M.; Al-Qarawi, A. A.; Ali, B. H.; Rahman, H. A A; Elmougy, S. A.

In: Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, Vol. 49, No. 10, 2002, p. 531-534.

Research output: Contribution to journalArticle

Mousa, H. M. ; Al-Qarawi, A. A. ; Ali, B. H. ; Rahman, H. A A ; Elmougy, S. A. / Effect of lead exposure on the erythrocytic antioxidant levels in goats. In: Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine. 2002 ; Vol. 49, No. 10. pp. 531-534.
@article{b4dadb96262a45e39eb85f85e7014818,
title = "Effect of lead exposure on the erythrocytic antioxidant levels in goats",
abstract = "Fifteen adult female goats were orally exposed to 5.46 mg lead (as lead acetate) per kg body weight daily for 2 weeks to study the antioxidant enzymes of the erythrocyte, lipid peroxide level, total thiol groups and total antioxidant status (TAS) in plasma. Ten goats served as unexposed control. Blood samples were collected before exposure (day O) and on days 7 and 14. Ten per cent erythrocyte haemolysate was prepared and analysed for glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), total thiol groups and lipid peroxide. TAS was determined in plasma. There was a significant (P <0.05) increase of erythrocytic GPx, SOD, CAT, total thiol groups and TAS on day 7 which was followed by a significant (P <0.05) decrease of all these parameters on day 14. Lipid peroxide level increased significantly (P <0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity.",
author = "Mousa, {H. M.} and Al-Qarawi, {A. A.} and Ali, {B. H.} and Rahman, {H. A A} and Elmougy, {S. A.}",
year = "2002",
language = "English",
volume = "49",
pages = "531--534",
journal = "Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine",
issn = "1865-1674",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Effect of lead exposure on the erythrocytic antioxidant levels in goats

AU - Mousa, H. M.

AU - Al-Qarawi, A. A.

AU - Ali, B. H.

AU - Rahman, H. A A

AU - Elmougy, S. A.

PY - 2002

Y1 - 2002

N2 - Fifteen adult female goats were orally exposed to 5.46 mg lead (as lead acetate) per kg body weight daily for 2 weeks to study the antioxidant enzymes of the erythrocyte, lipid peroxide level, total thiol groups and total antioxidant status (TAS) in plasma. Ten goats served as unexposed control. Blood samples were collected before exposure (day O) and on days 7 and 14. Ten per cent erythrocyte haemolysate was prepared and analysed for glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), total thiol groups and lipid peroxide. TAS was determined in plasma. There was a significant (P <0.05) increase of erythrocytic GPx, SOD, CAT, total thiol groups and TAS on day 7 which was followed by a significant (P <0.05) decrease of all these parameters on day 14. Lipid peroxide level increased significantly (P <0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity.

AB - Fifteen adult female goats were orally exposed to 5.46 mg lead (as lead acetate) per kg body weight daily for 2 weeks to study the antioxidant enzymes of the erythrocyte, lipid peroxide level, total thiol groups and total antioxidant status (TAS) in plasma. Ten goats served as unexposed control. Blood samples were collected before exposure (day O) and on days 7 and 14. Ten per cent erythrocyte haemolysate was prepared and analysed for glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), total thiol groups and lipid peroxide. TAS was determined in plasma. There was a significant (P <0.05) increase of erythrocytic GPx, SOD, CAT, total thiol groups and TAS on day 7 which was followed by a significant (P <0.05) decrease of all these parameters on day 14. Lipid peroxide level increased significantly (P <0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity.

UR - http://www.scopus.com/inward/record.url?scp=0036984408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036984408&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 531

EP - 534

JO - Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

JF - Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

SN - 1865-1674

IS - 10

ER -