TY - JOUR
T1 - Effect of lead exposure on the erythrocytic antioxidant levels in goats
AU - Mousa, H. M.
AU - Al-Qarawi, A. A.
AU - Ali, B. H.
AU - Abdel Rahman, H. A.
AU - ElMougy, S. A.
PY - 2002
Y1 - 2002
N2 - Fifteen adult female goats were orally exposed to 5.46 mg lead (as lead acetate) per kg body weight daily for 2 weeks to study the antioxidant enzymes of the erythrocyte, lipid peroxide level, total thiol groups and total antioxidant status (TAS) in plasma. Ten goats served as unexposed control. Blood samples were collected before exposure (day O) and on days 7 and 14. Ten per cent erythrocyte haemolysate was prepared and analysed for glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), total thiol groups and lipid peroxide. TAS was determined in plasma. There was a significant (P < 0.05) increase of erythrocytic GPx, SOD, CAT, total thiol groups and TAS on day 7 which was followed by a significant (P < 0.05) decrease of all these parameters on day 14. Lipid peroxide level increased significantly (P < 0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity.
AB - Fifteen adult female goats were orally exposed to 5.46 mg lead (as lead acetate) per kg body weight daily for 2 weeks to study the antioxidant enzymes of the erythrocyte, lipid peroxide level, total thiol groups and total antioxidant status (TAS) in plasma. Ten goats served as unexposed control. Blood samples were collected before exposure (day O) and on days 7 and 14. Ten per cent erythrocyte haemolysate was prepared and analysed for glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), total thiol groups and lipid peroxide. TAS was determined in plasma. There was a significant (P < 0.05) increase of erythrocytic GPx, SOD, CAT, total thiol groups and TAS on day 7 which was followed by a significant (P < 0.05) decrease of all these parameters on day 14. Lipid peroxide level increased significantly (P < 0.05) and the maximum level was attained by day 14. The results obtained indicate a possible role of free radicals in lead poisoning pathogenicity.
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U2 - 10.1046/j.1439-0442.2002.00499.x
DO - 10.1046/j.1439-0442.2002.00499.x
M3 - Article
C2 - 12549833
AN - SCOPUS:0036984408
SN - 0931-184X
VL - 49
SP - 531
EP - 534
JO - Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine
JF - Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine
IS - 10
ER -