Abstract
We investigated the effect of intermedin/adrenomedullin-2 (3 and 10 nmol/kg, i.v.), a member of the calcitonin gene-related peptide family, relative to the vehicle (0.9% NaCl) on mean circulatory filling pressure (index of venous tone) in conscious rats: intact (unblocked) or ganglionic blocked through treatment with mecamylamine (10 mg/kg, i.v.) and noradrenaline (4 μg/kg/min, i.v.). In intact rats, both doses of intermedin/adrenomedullin-2 reduced mean arterial pressure (-14±3, -30±3 mmHg), but did not alter mean circulatory filling pressure; the high dose also increased heart rate. In ganglionic-blocked rats, both doses decreased mean arterial pressure (-22±3, -46±5 mmHg) and the high dose also decreased mean circulatory filling pressure (-2.81±0.82 mmHg), but neither dose affected heart rate. The vehicle did not have any effects in any of the groups. In addition, intermedin/adrenomedullin-2 did not have any effect on blood volume in both intact and ganglion-blocked rats. The results show that intermedin/adrenomedullin-2 is a dilator of arterial resistance and capacitance vessels.
| Original language | English |
|---|---|
| Pages (from-to) | 376-380 |
| Number of pages | 5 |
| Journal | Naunyn-Schmiedeberg's Archives of Pharmacology |
| Volume | 373 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Aug 2006 |
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Keywords
- Adrenomedullin-2
- Blood volume
- Capacitance
- Ganglionic blockade
- Intermedin
- Mean arterial pressure
- Mean circulatory filling pressure
- Venous tone
ASJC Scopus subject areas
- Pharmacology
Cite this
Effect of intermedin/adrenomedullin-2 on venous tone in conscious rats. / Abdelrahman, Aly M.; Pang, Catherine C Y.
In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 373, No. 5, 08.2006, p. 376-380.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of intermedin/adrenomedullin-2 on venous tone in conscious rats
AU - Abdelrahman, Aly M.
AU - Pang, Catherine C Y
PY - 2006/8
Y1 - 2006/8
N2 - We investigated the effect of intermedin/adrenomedullin-2 (3 and 10 nmol/kg, i.v.), a member of the calcitonin gene-related peptide family, relative to the vehicle (0.9% NaCl) on mean circulatory filling pressure (index of venous tone) in conscious rats: intact (unblocked) or ganglionic blocked through treatment with mecamylamine (10 mg/kg, i.v.) and noradrenaline (4 μg/kg/min, i.v.). In intact rats, both doses of intermedin/adrenomedullin-2 reduced mean arterial pressure (-14±3, -30±3 mmHg), but did not alter mean circulatory filling pressure; the high dose also increased heart rate. In ganglionic-blocked rats, both doses decreased mean arterial pressure (-22±3, -46±5 mmHg) and the high dose also decreased mean circulatory filling pressure (-2.81±0.82 mmHg), but neither dose affected heart rate. The vehicle did not have any effects in any of the groups. In addition, intermedin/adrenomedullin-2 did not have any effect on blood volume in both intact and ganglion-blocked rats. The results show that intermedin/adrenomedullin-2 is a dilator of arterial resistance and capacitance vessels.
AB - We investigated the effect of intermedin/adrenomedullin-2 (3 and 10 nmol/kg, i.v.), a member of the calcitonin gene-related peptide family, relative to the vehicle (0.9% NaCl) on mean circulatory filling pressure (index of venous tone) in conscious rats: intact (unblocked) or ganglionic blocked through treatment with mecamylamine (10 mg/kg, i.v.) and noradrenaline (4 μg/kg/min, i.v.). In intact rats, both doses of intermedin/adrenomedullin-2 reduced mean arterial pressure (-14±3, -30±3 mmHg), but did not alter mean circulatory filling pressure; the high dose also increased heart rate. In ganglionic-blocked rats, both doses decreased mean arterial pressure (-22±3, -46±5 mmHg) and the high dose also decreased mean circulatory filling pressure (-2.81±0.82 mmHg), but neither dose affected heart rate. The vehicle did not have any effects in any of the groups. In addition, intermedin/adrenomedullin-2 did not have any effect on blood volume in both intact and ganglion-blocked rats. The results show that intermedin/adrenomedullin-2 is a dilator of arterial resistance and capacitance vessels.
KW - Adrenomedullin-2
KW - Blood volume
KW - Capacitance
KW - Ganglionic blockade
KW - Intermedin
KW - Mean arterial pressure
KW - Mean circulatory filling pressure
KW - Venous tone
UR - http://www.scopus.com/inward/record.url?scp=33747053135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747053135&partnerID=8YFLogxK
U2 - 10.1007/s00210-006-0076-z
DO - 10.1007/s00210-006-0076-z
M3 - Article
VL - 373
SP - 376
EP - 380
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
SN - 0028-1298
IS - 5
ER -