Effect of intermedin/adrenomedullin-2 on venous tone in conscious rats

Aly M. Abdelrahman, Catherine C Y Pang*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated the effect of intermedin/adrenomedullin-2 (3 and 10 nmol/kg, i.v.), a member of the calcitonin gene-related peptide family, relative to the vehicle (0.9% NaCl) on mean circulatory filling pressure (index of venous tone) in conscious rats: intact (unblocked) or ganglionic blocked through treatment with mecamylamine (10 mg/kg, i.v.) and noradrenaline (4 μg/kg/min, i.v.). In intact rats, both doses of intermedin/adrenomedullin-2 reduced mean arterial pressure (-14±3, -30±3 mmHg), but did not alter mean circulatory filling pressure; the high dose also increased heart rate. In ganglionic-blocked rats, both doses decreased mean arterial pressure (-22±3, -46±5 mmHg) and the high dose also decreased mean circulatory filling pressure (-2.81±0.82 mmHg), but neither dose affected heart rate. The vehicle did not have any effects in any of the groups. In addition, intermedin/adrenomedullin-2 did not have any effect on blood volume in both intact and ganglion-blocked rats. The results show that intermedin/adrenomedullin-2 is a dilator of arterial resistance and capacitance vessels.

Original languageEnglish
Pages (from-to)376-380
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume373
Issue number5
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Adrenomedullin-2
  • Blood volume
  • Capacitance
  • Ganglionic blockade
  • Intermedin
  • Mean arterial pressure
  • Mean circulatory filling pressure
  • Venous tone

ASJC Scopus subject areas

  • Pharmacology

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