Effect of infliximab and tocilizumab on fructose-induced hyperinsulinemia and hypertension in rats

Aly Abdelrahman, Yousuf Al Suleimani, Mohammed Ashique, Priyadarsini Manoj, Badreldin Ali

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fructose administration can induce hypertension, insulin resistance and hypertriglyceridemia. Here, we investigated the possible protective effect of infliximab (IFX), a tumor necrosis factor alpha (TNF-α) inhibitor, or tocilizumab (TOC), an interleukin-6 (IL6) inhibitor, on fructose-induced increase in blood pressure, insulin resistance and hyperlipidemia in rats. The animals were fed a 60% fructose diet in the absence or presence of IFX (5 mg/kg, i.p., once weekly) or TOC (8 mg/kg, i.p., once every two weeks). Fructose significantly increased blood pressure, heart rate and homeostatic model assessment of insulin resistance (HOMA-IR). Fructose also significantly raised the concentrations of fasting plasma insulin, triglycerides, total cholesterol, uric acid, tumor necrosis factor–alpha (TNF-α), interleukin 6 (IL-6), malondialdhyde (MDA) and nitric oxide. Fructose also significantly decreased plasma superoxide dismutase (SOD) and catalase activities. In addition, fructose significantly increased aortic endothelin and nitric oxide concentrations. Both IFX and TOC attenuated the fructose-induced increase in blood pressure, insulin resistance, and the concentrations of uric acid, MDA and IL-6. TOC significantly reduced fructose-induced increase in triglycerides and cholesterol. In addition, IFX increased plasma SOD and catalase activities. Our results showed that both IFX and TOC were partially successful in reversing fructose – induced changes.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalBiomedicine and Pharmacotherapy
Volume105
DOIs
Publication statusPublished - Sep 1 2018

Keywords

  • Blood pressure
  • Fructose
  • Infliximab
  • Insulin resistance
  • Tocilizumab

ASJC Scopus subject areas

  • Pharmacology

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