Effect of hemolysis on plasma cardiac troponin levels at clinically relevant concentrations

An experimental study

Maya Al-Shidhani, Huda Al Saadi, Waad Allah Mula-Abed, Nafila B. Al Riyami

Research output: Contribution to journalArticle

Abstract

Hemolysis is one of the most commonly encountered pre-analytical sources of interference in the Clinical Biochemistry laboratory. Hemolysis is known to cause a variable interference in both cardiac troponin I (cTnI) and troponin T (cTnT) assays. Each laboratory should determine and publicize these effects. In this experimental study we determined the effect of in-vitro sample hemolysis on both types of cardiac troponin assays and whether the effect was clinically significant.

Original languageEnglish
Article number1000217
JournalBiology and Medicine
Volume6
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Troponin
Hemolysis
Assays
Plasmas
Troponin T
Biochemistry
Troponin I

Keywords

  • Cardiac troponin
  • cTnI
  • cTnT
  • Hemolysis
  • Interference
  • Oman

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of hemolysis on plasma cardiac troponin levels at clinically relevant concentrations : An experimental study. / Al-Shidhani, Maya; Al Saadi, Huda; Mula-Abed, Waad Allah; Al Riyami, Nafila B.

In: Biology and Medicine, Vol. 6, No. 4, 1000217, 2014.

Research output: Contribution to journalArticle

@article{38516b04df4c46bdb82cc9b0764d6e6c,
title = "Effect of hemolysis on plasma cardiac troponin levels at clinically relevant concentrations: An experimental study",
abstract = "Hemolysis is one of the most commonly encountered pre-analytical sources of interference in the Clinical Biochemistry laboratory. Hemolysis is known to cause a variable interference in both cardiac troponin I (cTnI) and troponin T (cTnT) assays. Each laboratory should determine and publicize these effects. In this experimental study we determined the effect of in-vitro sample hemolysis on both types of cardiac troponin assays and whether the effect was clinically significant.",
keywords = "Cardiac troponin, cTnI, cTnT, Hemolysis, Interference, Oman",
author = "Maya Al-Shidhani and {Al Saadi}, Huda and Mula-Abed, {Waad Allah} and {Al Riyami}, {Nafila B.}",
year = "2014",
doi = "10.4172/0974-8369.1000217",
language = "English",
volume = "6",
journal = "Biology and Medicine",
issn = "0974-8369",
publisher = "Biology and Medicine Journal",
number = "4",

}

TY - JOUR

T1 - Effect of hemolysis on plasma cardiac troponin levels at clinically relevant concentrations

T2 - An experimental study

AU - Al-Shidhani, Maya

AU - Al Saadi, Huda

AU - Mula-Abed, Waad Allah

AU - Al Riyami, Nafila B.

PY - 2014

Y1 - 2014

N2 - Hemolysis is one of the most commonly encountered pre-analytical sources of interference in the Clinical Biochemistry laboratory. Hemolysis is known to cause a variable interference in both cardiac troponin I (cTnI) and troponin T (cTnT) assays. Each laboratory should determine and publicize these effects. In this experimental study we determined the effect of in-vitro sample hemolysis on both types of cardiac troponin assays and whether the effect was clinically significant.

AB - Hemolysis is one of the most commonly encountered pre-analytical sources of interference in the Clinical Biochemistry laboratory. Hemolysis is known to cause a variable interference in both cardiac troponin I (cTnI) and troponin T (cTnT) assays. Each laboratory should determine and publicize these effects. In this experimental study we determined the effect of in-vitro sample hemolysis on both types of cardiac troponin assays and whether the effect was clinically significant.

KW - Cardiac troponin

KW - cTnI

KW - cTnT

KW - Hemolysis

KW - Interference

KW - Oman

UR - http://www.scopus.com/inward/record.url?scp=84920969973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920969973&partnerID=8YFLogxK

U2 - 10.4172/0974-8369.1000217

DO - 10.4172/0974-8369.1000217

M3 - Article

VL - 6

JO - Biology and Medicine

JF - Biology and Medicine

SN - 0974-8369

IS - 4

M1 - 1000217

ER -