Effect of grapefruit juice on drug metabolism in rats

S. I. Sharif, B. H. Ali

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of grapefruit juice on in vivo drug metabolism was investigated in rats. The juice (4 ml or 8 ml/kg) was given orally once daily for 2 consecutive days and its effect on theophylline metabolism, pentobarbitone sleeping time and the tremorgenic action of tremorine was studied. The effect of grapefruit juice on some of these parameters was compared with that of the known drug metabolism inhibitor cimetidine given ip. Grapefruit juice at 4 ml and 8 ml/kg produced significant increases in pentobarbitone sleeping time that reached 46 and 79%, respectively, compared with 107% produced by cimetidine (50 mg/kg, ip). The juice at 4 ml/kg also significantly increased plasma theophylline concentration when measured 15, 30, 60 and 90 min after ip theophylline administration (10 mg/kg). Thereafter, no significant differences were detected in plasma drug concentrations between juice- and saline-treated animals. Administration of tremorine (25 mg/kg, ip) to saline-treated controls produced, within 2 or 3 min, tremors, piloerection, profuse salivation, defaecation, urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to about 7 min in rats pretreated 1 hr earlier with either grapefruit juice (4 ml/kg, orally) or cimetidine (50 mg/kg, ip). The severity of the above signs was markedly reduced to a similar extent in both the juice- and cimetidine-treated rats. These results suggest that grapefruit juice may act as an inhibitor of drug metabolism in rats, and that its consumption may alter the disposition of certain concomitantly administered drugs.

Original languageEnglish
Pages (from-to)1169-1171
Number of pages3
JournalFood and Chemical Toxicology
Volume32
Issue number12
DOIs
Publication statusPublished - 1994

Fingerprint

grapefruit juice
Citrus paradisi
cimetidine
Metabolism
pharmacokinetics
Cimetidine
Rats
theophylline
Tremorine
juices
Theophylline
rats
Pharmaceutical Preparations
Pentobarbital
Piloerection
Salivation
Plasmas
urination
drugs
salivation

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Effect of grapefruit juice on drug metabolism in rats. / Sharif, S. I.; Ali, B. H.

In: Food and Chemical Toxicology, Vol. 32, No. 12, 1994, p. 1169-1171.

Research output: Contribution to journalArticle

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