Abstract
The effect of fish oil on gentamicin-induced nephrotoxicity was investigated in rats. Gentamicin (80 mg/kg/day intramuscularly for 6 days) produced the typical pattern of nephrotoxicity as shown by increases in serum creatinine and urea concentrations, and urinary N-acetyl-β-D-glucosaminidase (NAG) activity and proximal renal tubular necrosis. Fish oil (5.0 ml/kg/kday per os for 10 days) partially protected against the nephrotoxicity induced by gentamicin administered during the last 6 days of treatment with fish oil by returning the creatinine and urea concentrations and NAG activity to normal and by ameliorating the histopathological damage. Olive oil (5 mg/kg/day per os for 10 days) was ineffective in protecting rats against gentamicin nephrotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 336-339 |
| Number of pages | 4 |
| Journal | Annals of Nutrition and Metabolism |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1994 |
| Externally published | Yes |
Keywords
- Fish oil
- Gentamicin
- Nephrotoxicity
- Olive oil
- Rats
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics