Effect of fish oil treatment on gentamicin nephrotoxicity in rats

B. H. Ali, A. A. Bashir

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Abstract

The effect of fish oil on gentamicin-induced nephrotoxicity was investigated in rats. Gentamicin (80 mg/kg/day intramuscularly for 6 days) produced the typical pattern of nephrotoxicity as shown by increases in serum creatinine and urea concentrations, and urinary N-acetyl-β-D-glucosaminidase (NAG) activity and proximal renal tubular necrosis. Fish oil (5.0 ml/kg/kday per os for 10 days) partially protected against the nephrotoxicity induced by gentamicin administered during the last 6 days of treatment with fish oil by returning the creatinine and urea concentrations and NAG activity to normal and by ameliorating the histopathological damage. Olive oil (5 mg/kg/day per os for 10 days) was ineffective in protecting rats against gentamicin nephrotoxicity.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalAnnals of Nutrition and Metabolism
Volume38
Issue number6
DOIs
Publication statusPublished - 1994

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Keywords

  • Fish oil
  • Gentamicin
  • Nephrotoxicity
  • Olive oil
  • Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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