Abstract
The effect of endotoxin administration on gentamicin pharmacokinetics in young adult (2-3 months) and old (22-24 months) rats was studied. Gentamicin (3 mg/kg, iv) was administered 24 hours after an endotoxin challenge (5 mg/kg, ip). Some blood biochemical parameters, viz. urea, AST, GGT activities in addition to PCV and Hb concentration and creatinine clearance were also measured. In young animals, endotoxin caused prolongation in gentamicin half life (t( 1/4 )), increased area under the plasma concentration-time curve (AUC) and reduced total body clearance (Cl(B)) and volume of distribution (V(d)). Endotoxin effects in the old rats were qualitatively similar to those induced in the young but were more pronounced. They included more than 10 fold increase in the t( 1/4 ) and AUC. In addition, a rising early phase in gentamicin plasma concentration was noticed in old rats treated with endotoxin which was, probably, due to an early redistribution process of gentamicin. The results indicate that aging and endotoxin, individually, can significantly alter gentamicin pharmacokinetics in the rat. These alterations were exacerbated when endotoxemia was induced in old rats.
| Original language | English |
|---|---|
| Pages (from-to) | 413-424 |
| Number of pages | 12 |
| Journal | Life Sciences |
| Volume | 60 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jan 3 1997 |
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Keywords
- aging
- endotoxin
- gentamicin
- pharmacokinetics
ASJC Scopus subject areas
- Pharmacology
Cite this
Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats. / Tanira, Musbah O M; Ali, B. H.; Bashir, A. K.
In: Life Sciences, Vol. 60, No. 6, 03.01.1997, p. 413-424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats
AU - Tanira, Musbah O M
AU - Ali, B. H.
AU - Bashir, A. K.
PY - 1997/1/3
Y1 - 1997/1/3
N2 - The effect of endotoxin administration on gentamicin pharmacokinetics in young adult (2-3 months) and old (22-24 months) rats was studied. Gentamicin (3 mg/kg, iv) was administered 24 hours after an endotoxin challenge (5 mg/kg, ip). Some blood biochemical parameters, viz. urea, AST, GGT activities in addition to PCV and Hb concentration and creatinine clearance were also measured. In young animals, endotoxin caused prolongation in gentamicin half life (t( 1/4 )), increased area under the plasma concentration-time curve (AUC) and reduced total body clearance (Cl(B)) and volume of distribution (V(d)). Endotoxin effects in the old rats were qualitatively similar to those induced in the young but were more pronounced. They included more than 10 fold increase in the t( 1/4 ) and AUC. In addition, a rising early phase in gentamicin plasma concentration was noticed in old rats treated with endotoxin which was, probably, due to an early redistribution process of gentamicin. The results indicate that aging and endotoxin, individually, can significantly alter gentamicin pharmacokinetics in the rat. These alterations were exacerbated when endotoxemia was induced in old rats.
AB - The effect of endotoxin administration on gentamicin pharmacokinetics in young adult (2-3 months) and old (22-24 months) rats was studied. Gentamicin (3 mg/kg, iv) was administered 24 hours after an endotoxin challenge (5 mg/kg, ip). Some blood biochemical parameters, viz. urea, AST, GGT activities in addition to PCV and Hb concentration and creatinine clearance were also measured. In young animals, endotoxin caused prolongation in gentamicin half life (t( 1/4 )), increased area under the plasma concentration-time curve (AUC) and reduced total body clearance (Cl(B)) and volume of distribution (V(d)). Endotoxin effects in the old rats were qualitatively similar to those induced in the young but were more pronounced. They included more than 10 fold increase in the t( 1/4 ) and AUC. In addition, a rising early phase in gentamicin plasma concentration was noticed in old rats treated with endotoxin which was, probably, due to an early redistribution process of gentamicin. The results indicate that aging and endotoxin, individually, can significantly alter gentamicin pharmacokinetics in the rat. These alterations were exacerbated when endotoxemia was induced in old rats.
KW - aging
KW - endotoxin
KW - gentamicin
KW - pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=0031040342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031040342&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(96)00666-2
DO - 10.1016/S0024-3205(96)00666-2
M3 - Article
VL - 60
SP - 413
EP - 424
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 6
ER -