EFFECT OF DIMETHYLSULPHOXIDE ON CYSTEAMINE‐INDUCED DUODENAL ULCERATION IN RATS

B. H. Ali

doi:10.1111/j.1440-1681.1990.tb01345.x

EFFECT OF DIMETHYLSULPHOXIDE ON CYSTEAMINE‐INDUCED DUODENAL ULCERATION IN RATS

B. H. Ali^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

1. Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4 and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. 2. DMSO reduced, in a dose‐dependent manner, the incidence and extent of the ulceration. 3. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1111/j.1440-1681.1990.tb01345.x
Publication status	Published - Jun 1990
Externally published	Yes

Keywords

cysteamine
dimethylsulphoxide
duodenal ulceration.

ASJC Scopus subject areas

Physiology
Pharmacology
Physiology (medical)

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10.1111/j.1440-1681.1990.tb01345.x

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N2 - 1. Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4 and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. 2. DMSO reduced, in a dose‐dependent manner, the incidence and extent of the ulceration. 3. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

AB - 1. Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4 and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. 2. DMSO reduced, in a dose‐dependent manner, the incidence and extent of the ulceration. 3. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

KW - cysteamine

KW - dimethylsulphoxide

KW - duodenal ulceration.

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SN - 0305-1870

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EP - 466

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

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ER -

EFFECT OF DIMETHYLSULPHOXIDE ON CYSTEAMINE‐INDUCED DUODENAL ULCERATION IN RATS

Abstract

Keywords

ASJC Scopus subject areas

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