Effect of dimethylsulphoxide on cysteamine-induced duodenal ulceration in rats

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4, and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume17
Issue number6
Publication statusPublished - 1990

Fingerprint

Cysteamine
Dimethyl Sulfoxide
Mucus
Drinking Water
Incidence

Keywords

  • cysteamine
  • dimethylsulphoxide
  • duodenal ulceration

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of dimethylsulphoxide on cysteamine-induced duodenal ulceration in rats. / Ali, B. H.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 17, No. 6, 1990, p. 463-466.

Research output: Contribution to journalArticle

@article{7cae1cdec9164bf5adec89e0c4313211,
title = "Effect of dimethylsulphoxide on cysteamine-induced duodenal ulceration in rats",
abstract = "Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4, and 6{\%} v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.",
keywords = "cysteamine, dimethylsulphoxide, duodenal ulceration",
author = "Ali, {B. H.}",
year = "1990",
language = "English",
volume = "17",
pages = "463--466",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Effect of dimethylsulphoxide on cysteamine-induced duodenal ulceration in rats

AU - Ali, B. H.

PY - 1990

Y1 - 1990

N2 - Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4, and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

AB - Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4, and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

KW - cysteamine

KW - dimethylsulphoxide

KW - duodenal ulceration

UR - http://www.scopus.com/inward/record.url?scp=0025316073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025316073&partnerID=8YFLogxK

M3 - Article

C2 - 2390808

AN - SCOPUS:0025316073

VL - 17

SP - 463

EP - 466

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 6

ER -