Effect of dimethylsulphoxide on cysteamine-induced duodenal ulceration in rats

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3 Citations (Scopus)

Abstract

Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4, and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume17
Issue number6
Publication statusPublished - 1990

Keywords

  • cysteamine
  • dimethylsulphoxide
  • duodenal ulceration

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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