Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4, and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.
|Number of pages||4|
|Journal||Clinical and Experimental Pharmacology and Physiology|
|Publication status||Published - 1990|
- duodenal ulceration
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)