Effect of composition and quality of diet and feeding time on the kinetics and efficacy of some anthelmintic drugs

A mini-review

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This article reviews the literature dealing with the effects of composition and quality of diet and feeding time on the pharmacokinetics and efficacy of some anthelmintic drugs in ruminants. Studies have suggested that greater availability, and therefore improved anthelmintic activity, is possible through temporary feed restriction. It is also recommended that anthelmintic drugs should not be given to animals whilst they are maintained on large feed intakes, particularly of lush pasture that promotes rapid gastric transit, as this may reduce drug availability and anthelmintic efficacy. Generally, feeding animals low-quality fibrous diets reduces the passage rate of digesta and allows more time for absorption of several anthelmintic drugs and their metabolites from the gut. Some kinetic data of drugs given to animals on such diets may be slightly different, but this does not necessarily indicate alteration of the dosages of the anthelmintic drug. Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times.

Original languageEnglish
Pages (from-to)339-347
Number of pages9
JournalActa Veterinaria Hungarica
Volume52
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

Anthelmintics
nutritional adequacy
anthelmintics
Diet
kinetics
drugs
Pharmaceutical Preparations
Pharmacokinetics
animal feeding
restricted feeding
Ruminants
digesta
dosage
diet
pharmacokinetics
ruminants
Stomach
animals
stomach
feed intake

Keywords

  • Anthelmintics
  • Cattle
  • Feed
  • Feed restriction
  • Kinetics
  • Sheep

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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abstract = "This article reviews the literature dealing with the effects of composition and quality of diet and feeding time on the pharmacokinetics and efficacy of some anthelmintic drugs in ruminants. Studies have suggested that greater availability, and therefore improved anthelmintic activity, is possible through temporary feed restriction. It is also recommended that anthelmintic drugs should not be given to animals whilst they are maintained on large feed intakes, particularly of lush pasture that promotes rapid gastric transit, as this may reduce drug availability and anthelmintic efficacy. Generally, feeding animals low-quality fibrous diets reduces the passage rate of digesta and allows more time for absorption of several anthelmintic drugs and their metabolites from the gut. Some kinetic data of drugs given to animals on such diets may be slightly different, but this does not necessarily indicate alteration of the dosages of the anthelmintic drug. Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times.",
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N2 - This article reviews the literature dealing with the effects of composition and quality of diet and feeding time on the pharmacokinetics and efficacy of some anthelmintic drugs in ruminants. Studies have suggested that greater availability, and therefore improved anthelmintic activity, is possible through temporary feed restriction. It is also recommended that anthelmintic drugs should not be given to animals whilst they are maintained on large feed intakes, particularly of lush pasture that promotes rapid gastric transit, as this may reduce drug availability and anthelmintic efficacy. Generally, feeding animals low-quality fibrous diets reduces the passage rate of digesta and allows more time for absorption of several anthelmintic drugs and their metabolites from the gut. Some kinetic data of drugs given to animals on such diets may be slightly different, but this does not necessarily indicate alteration of the dosages of the anthelmintic drug. Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times.

AB - This article reviews the literature dealing with the effects of composition and quality of diet and feeding time on the pharmacokinetics and efficacy of some anthelmintic drugs in ruminants. Studies have suggested that greater availability, and therefore improved anthelmintic activity, is possible through temporary feed restriction. It is also recommended that anthelmintic drugs should not be given to animals whilst they are maintained on large feed intakes, particularly of lush pasture that promotes rapid gastric transit, as this may reduce drug availability and anthelmintic efficacy. Generally, feeding animals low-quality fibrous diets reduces the passage rate of digesta and allows more time for absorption of several anthelmintic drugs and their metabolites from the gut. Some kinetic data of drugs given to animals on such diets may be slightly different, but this does not necessarily indicate alteration of the dosages of the anthelmintic drug. Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times.

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