Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats

Azza A K El-Sheikh, Mohamed A. Morsy, Marwa M. Mahmoud, Rehab A. Rifaai, Aly M. Abdelrahman

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Abstract

Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved. Two doses (10 and 100 mg/kg) of CoQ10 were administered orally to rats for 8 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of Dox (15 mg/kg) at day 4 of the experiment. Our results showed that the low dose of CoQ10 succeeded in reversing Dox-induced nephrotoxicity to control levels (e.g., levels of blood urea nitrogen and serum creatinine, concentrations of renal reduced glutathione (GSH) and malondialdehyde, catalase activity and caspase 3 expression, and renal histopathology). Alternatively, the high dose of CoQ10 showed no superior nephroprotection over the low dose, as there were no significant improvements in renal histopathology, catalase activity, or caspase 3 expression compared to the Dox-treated group. Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10. We conclude that CoQ10 protects from Dox-induced nephrotoxicity with a precaution to dosage adjustment.

Original languageEnglish
Article number981461
JournalAdvances in Pharmacological Sciences
Volume2012
DOIs
Publication statusPublished - 2012

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coenzyme Q10
Doxorubicin
Caspase 3
Catalase
Kidney
Blood Urea Nitrogen
Intraperitoneal Injections
Malondialdehyde
Glutathione

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats. / El-Sheikh, Azza A K; Morsy, Mohamed A.; Mahmoud, Marwa M.; Rifaai, Rehab A.; Abdelrahman, Aly M.

In: Advances in Pharmacological Sciences, Vol. 2012, 981461, 2012.

Research output: Contribution to journalArticle

El-Sheikh, Azza A K ; Morsy, Mohamed A. ; Mahmoud, Marwa M. ; Rifaai, Rehab A. ; Abdelrahman, Aly M. / Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats. In: Advances in Pharmacological Sciences. 2012 ; Vol. 2012.
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