Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease

Badreldin H. Ali, Lucie Cahliková, Lubomir Opletal, Turan Karaca, Priyadarsini Manoj, Aishwarya Ramkumar, Yousuf M. Al Suleimani, Mohammed Al Za'abi, Abderrahim Nemmar, Lucie Chocholousova-Havlikova, Miroslav Locarek, Tomas Siatka, Gerald Blunden

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: The aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model. Methods: Rats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg). Key findings: When either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril. Conclusions: The results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.

Original languageEnglish
Pages (from-to)1219-1229
Number of pages11
JournalJournal of Pharmacy and Pharmacology
Volume69
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • adenine
  • anthocyanins
  • chronic kidney disease
  • Hibiscus sabdariffa
  • rats

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Ali, B. H., Cahliková, L., Opletal, L., Karaca, T., Manoj, P., Ramkumar, A., Al Suleimani, Y. M., Al Za'abi, M., Nemmar, A., Chocholousova-Havlikova, L., Locarek, M., Siatka, T., & Blunden, G. (2017). Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease. Journal of Pharmacy and Pharmacology, 69(9), 1219-1229. https://doi.org/10.1111/jphp.12748